ArticleMicrobiology spectrum2024
Prognostic value of poly-microorganisms detected by droplet digital PCR and pathogen load kinetics in sepsis patients: a multi-center prospective cohort study.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Diagnostic performance and antibiotic impact of droplet digital PCR in suspected sepsis: the PROGRESS trial.Nature communications · 2026Trial
- The NLRP3 inflammasome in physiological and dysfunctional host response in human sepsis and critical illness: a narrative review.Critical care (London, England) · 2026Review
- A Dual-Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prognostic and clinical indicators of sepsis outcomes in hospitalized patients: a cross-sectional study.BMC infectious diseases · 2025Article
- Clinical diagnostic performance of droplet digital PCR for pathogen detection in patients with Escherichia coli bloodstream infection: a prospective observational study.BMC infectious diseases · 2025Observational
- ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI.Frontiers in cellular and infection microbiology · 2025Article
- Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study.Frontiers in cellular and infection microbiology · 2024Article
Corrections and comments
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Authors and funding
38 authors at 8 institutions in 1 country.
Yuanhan Zhao *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5453-1515
Ke Lin *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.
Haocheng Zhang *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-0593-2563
Yanliang Zhang *Department of Infectious Diseases, The Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Shaling Li *Department of Infectious Diseases, Xiangya Hospital Central South University, Changsha, Hunan, China.
Shengguo Zhang *Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, WenZhou, Zhejiang, China.
Wei ZhangSociety of Clinical Epidemiology and Evidence-Based Medicine, Shanghai Medical Association, Shanghai, China.
Aiming ZhouDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yangyang ZhuangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jie ChenDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Caixia WuDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wei ZhouDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaoju HeDepartment of Infectious Diseases, The Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Qiaoyan YueDepartment of Infectious Diseases, The Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Meng ZhangDepartment of Infectious Diseases, The Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yan HuangDepartment of Infectious Diseases, Xiangya Hospital Central South University, Changsha, Hunan, China.
Liang LiDepartment of Infectious Diseases, Xiangya Hospital Central South University, Changsha, Hunan, China.
Liang HongDepartment of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, WenZhou, Zhejiang, China.
Fujing CaiDepartment of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, WenZhou, Zhejiang, China.
Lisu HuangDepartment of Infectious Disease, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhengshang RuanDepartment of Infectious Disease, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanshan XuDepartment of Infectious Disease, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan ZhangDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohua ChenDepartment of Infectious Diseases, Shanghai Sixth Hospital, Shanghai Jiaotong University, Shanghai, China.
Jie ChenDepartment of Infectious Diseases, Shanghai Sixth Hospital, Shanghai Jiaotong University, Shanghai, China.
Ying YeDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Tingting BianDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Jiabin LiDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0002-6539-1802
Jun YinDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xiang LiDepartment of Critical Care Medicine, Minhang Hospital, Fudan University, China, Shanghai.
Lijing JiangDepartment of Critical Care Medicine, Minhang Hospital, Fudan University, China, Shanghai.
Chen LeiDepartment of Critical Care Medicine, Minhang Hospital, Fudan University, China, Shanghai.
Jun LiuDepartment of Laboratory, Wuxi No.5 People's Hospital Affiliated to Nantong University, Nantong, China.
Ying ZhangDepartment of Laboratory, Wuxi No.5 People's Hospital Affiliated to Nantong University, Nantong, China.
Jialin JinDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.
Jingwen AiDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.
Jingye PanDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenhong ZhangDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNWenzhou Medical University · CNNanjing University of Chinese Medicine · CNAnhui Medical University · CNCentral South University · CNXinHua Hospital · CNNantong University · CNShanghai Sixth People's Hospital · CN
Funding
MOST | National Key Research and Development Program of China (NKPs) 2022YFC2009802MOST | National Natural Science Foundation of China (NSFC) 82002141Shanghai Municipal Science and Technology Major Project HS2021SHZX001Shanghai Science and Technology Committee 21NL2600100, 20dz2260100Shanghai Science and Technology Committee 21Y11902100Shanghai Science and Technology Committee 22YF1445800
Abstract
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used to assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators in a subgroup of the cohort. A total of 107 sepsis patients with positive baseline DDPCR results were included. Detection of poly-microorganisms [adjusted hazard ratio (HR) = 3.19; 95% confidence interval (CI) = 1.34-7.62;
Indexed as
Polymerase Chain ReactionSepsisAgedAged, 80 and overBacteriaBacterial LoadFemaleHumansKineticsMaleMiddle AgedPrognosisProspective StudiesRisk Factorsdroplet digital polymerase chain reactionmortalitypathogen loadpolymicrobial infectionsepsis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.