Evidence map›Paper›PMID 38526161›Full record

ArticleOphthalmic genetics2024

Genetic factors associated with age-related macular degeneration modulating plasma inflammatory biomarker levels in patients with AIDS.

Efe Sezgin, Michael F Schneider, Peter W Hunt, Gabriele Beck-Engeser, Gabriele C Ambayac, Douglas A Jabs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Efe SezginDepartment of Food Engineering, İzmir İnstitute of Technology, Izmir, Turkey.
Michael F SchneiderDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Peter W HuntDepartment of Medicine, School of Medicine, The University of California, San Francisco, San Francisco, California, USA.
Gabriele Beck-EngeserDepartment of Medicine, School of Medicine, The University of California, San Francisco, San Francisco, California, USA.
Gabriele C AmbayacDepartment of Medicine, School of Medicine, The University of California, San Francisco, San Francisco, California, USA.
Douglas A JabsDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
University of California, San Francisco · USJohns Hopkins University · USIzmir Institute of Technology · TR

Funding

Immunologic Determinants of Age-Related Macular Degeneration (AMD)R01EY025093 · NEI · JOHNS HOPKINS UNIVERSITY · PI JABS, DOUGLAS A · 2016 to 2024
$3.4M
NEI NIH HHS R01 EY025093
6 · The paper itself

Abstract

introductionPatients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in this population. We evaluated the association between AMD risk alleles and plasma inflammatory biomarker levels in persons with AIDS. MATERIALS AND

methodsCryopreserved plasma specimens of 229 non-Hispanic White and 252 non-Hispanic blacks from the Longitudinal Study of the Ocular Complications of AIDS cohort were assayed for plasma levels of soluble tumor necrosis factor receptor (sTNFR) 2, interleukin (IL)-18, C × 3motif chemokine ligand 1 (CX3CL1), C-reactive protein (CRP), and soluble CD14 (sCD14). Genotyping included AMD-associated variants rs10801553 and rs800292 for complement factor H (CFH) rs9332739 and rs547154 for complement factor 2 (C2), rs2230199 for C3, rs2285714 for CFI, and rs3732379 and rs3732378 for C × 3motif chemokine receptor 1 (CX3CR1).

resultsIn Whites, AMD low-risk CX3CR1 variants (V249I and T280M) were associated with reduced plasma levels of IL-18. In Blacks, AMD low-risk C3 R102G and low-risk CX3CR1 T280M variants were associated with reduced CRP levels.

conclusionsGenetic variants in AMD-associated immune genes may influence AMD-associated systemic plasma inflammatory biomarker levels in patients with AIDS.

Indexed as

Acquired Immunodeficiency SyndromeBiomarkersChemokine CX3CL1Macular DegenerationBlack or African AmericanComplement Factor HC-Reactive ProteinCX3C Chemokine Receptor 1FemaleGenotypeHumansInterleukin-18Lipopolysaccharide ReceptorsMaleMiddle AgedPolymorphism, Single NucleotideBiomarkersChemokine CX3CL1Complement Factor HC-Reactive ProteinCX3C Chemokine Receptor 1CX3CL1 protein, humanCX3CR1 protein, humanInterleukin-18Lipopolysaccharide ReceptorsReceptors, Tumor Necrosis Factor, Type IIAcquired immunodeficiency syndromeage-related macular degenerationgenetic risk factorsinflammatory biomarkers

Identifiers

PMID38526161
PMCPMC11387137
OpenAlexW4393145606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.