Evidence map›Paper›PMID 38526086›Full record

ArticleMicrobiology spectrum2024

When the Trojan horse is unable to reach inside the city: investigation of the mechanism of resistance behind the first reported cefiderocol-resistant

Kevin R Barker, Gabriel W Rebick, Ken Fakharuddin, Clayton MacDonald, Michael R Mulvey, Laura F Mataseje

Open access · goldAbstract readCase Reports
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kevin R BarkerMicrobiology, Department of Laboratory Medicine and Genetics, Trillium Health Partners, Mississauga, Ontario, Canada.ORCID 0000-0002-9288-6544
Gabriel W RebickDivision of Infectious Diseases, Department of Medicine, Trillium Health Partners, Mississauga, Ontario, Canada.
Ken FakharuddinPublic Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Canada.
Clayton MacDonaldMicrobiology, Department of Laboratory Medicine and Genetics, Trillium Health Partners, Mississauga, Ontario, Canada.
Michael R MulveyPublic Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Canada.
Laura F MatasejePublic Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Canada.ORCID 0000-0002-8014-1107
Public Health Agency of Canada · CATrillium Health Centre · CAUniversity of Toronto · CA

Funding

Public Health Agency of Canada (PHAC) na
6 · The paper itself

Abstract

Gram-negative metallo-β-lactamase-producing bacteria can be extremely problematic, especially when found to be extensively drug-resistant (XDR). Cefiderocol is a novel antimicrobial that has been shown to overcome most carbapenemases, with very rare resistance reported to date. Within our institution, two multidrug-resistant and one XDR strains were isolated from a patient who recently emigrated from India. Each isolate underwent whole-genome sequencing to resolve plasmids and determine phylogenetics, strain typing, and mechanisms of resistance. The XDR

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialEscherichia coli InfectionsAgedbeta-LactamasesCanadaCefiderocolCephalosporinsEscherichia coliEscherichia coli ProteinsHumansIndiaMaleMicrobial Sensitivity TestsMutationPhylogenyAnti-Bacterial Agentsbeta lactamase NDM-5, E colibeta-LactamasesCefiderocolCephalosporinsEscherichia coli Proteinsantimicrobial resistanceCanadacarbapenemasecarbapenem-resistant Enterobacteriaceaecefiderocolextensively drug-resistantST167XDR

Identifiers

PMID38526086
PMCPMC11064503
OpenAlexW4393161517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.