Evidence map›Paper›PMID 38526061›Full record

ArticleJournal of clinical microbiology2024

Performance evaluation of the high-throughput quantitative Alinity m BK virus assay.

Julie W Hirschhorn, Mark M Sasaki, April Kegl, Tanjina Akter, Tanisha Dickerson, Momka Narlieva, Nhi Nhan, Tianxi Liu, Patricia Jim, Stephen Young and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Julie W HirschhornDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Mark M SasakiMolecular Diagnostics of Abbott, Des Plaines, Illinois, USA.
April KeglDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Tanjina AkterDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Tanisha DickersonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Momka NarlievaDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Nhi NhanDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Tianxi LiuDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Patricia JimTriCore Reference Laboratories, Albuquerque, New Mexico, USA.
Stephen YoungTriCore Reference Laboratories, Albuquerque, New Mexico, USA.
Erika OrnerDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-6253-7298
Phyu ThweDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Danijela LucicMolecular Diagnostics of Abbott, Des Plaines, Illinois, USA.
D Yitzchak GoldsteinDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0001-6367-8335
Montefiore Medical Center · USMedical University of South Carolina · USAbbott (United States) · USApplied Research Associates (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BK virus (BKV) infection or reactivation in immunocompromised individuals can lead to adverse health consequences including BKV-associated nephropathy (BKVAN) in kidney transplant patients and BKV-associated hemorrhagic cystitis (BKV-HC) in allogeneic hematopoietic stem cell transplant recipients. Monitoring BKV viral load plays an important role in post-transplant patient care. This study evaluates the performance of the Alinity m BKV Investigational Use Only (IUO) assay. The linearity of the Alinity m BKV IUO assay had a correlation coefficient of 1.000 and precision of SD ≤ 0.25 Log IU/mL for all panel members tested (2.0-7.3 Log IU/mL). Detection rate at 50 IU/mL was 100%. Clinical plasma specimens tested comparing Alinity m BKV IUO to ELITech MGB Alert BKV lab-developed test (LDT) on the Abbott IMPORTANCE: BK virus (BKV) in transplant patients can lead to adverse health consequences. Viral load monitoring is important in post-transplant patient care. This study evaluates the Alinity m BKV assay with currently available assays.

Indexed as

BK VirusKidney TransplantationNucleic AcidsPolyomavirus InfectionsTumor Virus InfectionsHumansViral LoadNucleic AcidsBKVhigh-throughput diagnosticsnucleic acid amplification testtransplantationviral load monitoring

Identifiers

PMID38526061
PMCPMC11005350
OpenAlexW4393152341

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.