Evidence map›Paper›PMID 38525784›Full record

ArticleMethods and protocols2024

The Frailty Reduction via Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial: Study Protocol and Recruitment Results.

Michael Inskip, Carolina Almendrales Rangel, Chidiamara Maria Njoku, Fiona Barnett, Isabel Shih, Leonie O'Neill, Maria A Fiatarone Singh, Trinidad Valenzuela

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods and protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Michael InskipCollege of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia.ORCID 0000-0001-5150-8582
Carolina Almendrales RangelSchool of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0002-8664-563X
Chidiamara Maria NjokuCollege of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia.ORCID 0000-0003-3758-2422
Fiona BarnettCollege of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia.
Isabel ShihSchool of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.
Leonie O'NeillThe Good Shepherd Home, Townsville, QLD 4814, Australia.
Maria A Fiatarone SinghSchool of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0002-1897-8707
Trinidad ValenzuelaSchool of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.
The University of Sydney · AUJames Cook University · AU

Funding

Dementia Collaborative Research Centres Implementing Research Evidence into Practice GrantJames Cook University Philanthropic Chiropractic Research Fund
6 · The paper itself

Abstract

introductionVirtually all adults in aged care facilities are frail, a condition which contributes to falls, cognitive decline, hospitalisation, and mortality. Polypharmacy, malnutrition, sedentariness, and sarcopenia are risk factors amenable to intervention. The Asia-Pacific Frailty Management Guidelines recommend anabolic exercise and the optimisation of medications and nutrition. However, no study has evaluated this best practice intervention triad in aged care.

methodsThe Frailty Reduction via the Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial (ANZCTR No.ACTRN12622000926730p) is a staged 6-month translational trial evaluating resident outcomes, staff/caregiver knowledge, and institutional implementation in a Townsville aged care facility. Residents received high-intensity resistance exercise and balance training and medication and nutrition optimisation co-implemented by investigators (exercise physiologist, geriatrician, pharmacist, and nutritionist) and facility staff. Staff and caregivers completed comprehensive education modules and training. We report the trial protocol and recruitment results.

results29 residents (21 female, age: 88.6 ± 6.3 years) were recruited. At baseline, the residents were frail (frailty scale nursing home (FRAIL-NH); 6.3 ± 2.4/14), cognitively impaired (Montreal Cognitive Assessment; 13.8 ± 6.8/30), functionally impaired (Short Physical Performance Battery; 4.9 ± 3.1/12, 6 min walk distance; 222.2 ± 104.4 m), and were prescribed numerous medications (15.5 ± 5.9). Two residents died and one withdrew before the intervention's commencement. Thirty family members and 19 staff (carers, allied health assistants, nurse managers, registered nurses, lifestyle-leisure officers, kitchen/hospitality staff, and senior leadership) were recruited to receive frailty education modules.

conclusionsThe FRIEND trial is currently being implemented with results expected in mid-2024. This is the first trial to evaluate the implementation of the best practice frailty guidelines including anabolic exercise and medication/nutritional optimisation in residential aged care.

Indexed as

aged careexercisefrailtygerontologymedication optimisationnutrition

Identifiers

PMID38525784
PMCPMC10961770
OpenAlexW4393141962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.