ArticleThe Journal of clinical endocrinology and metabolism2025
Predicting Tumor Volume in Primary Hyperparathyroidism From Preoperative Clinical Data.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Correlation between preoperative biochemical indices and intraoperative findings in primary hyperparathyroidism.Gland surgery · 2026Article
- Ectopic parathyroid adenomas in primary hyperparathyroidism: anatomical classifications, localization strategies, and case series.International journal of surgery (London, England) · 2026Article
- A case report of primary hyperparathyroidism due to a giant substernal parathyroid adenoma managed using a neck incision approach.Medicine · 2025Article
- Association of preoperative risk factors with therapeutic outcomes in primary hyperparathyroidism: A multivariate analysis of imaging and PTH-Calcium-Phosphate metabolic parameters in 164 cases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- A Giant Ectopic Parathyroid Adenoma Mimicking Parathyroid Carcinoma.AACE endocrinology and diabetesArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPrimary hyperparathyroidism (PHPT) is an endocrine disorder that is treated surgically, and some correlation between the size of the responsible lesion and preoperative clinical data is assumed.
objectiveThe purpose of this study was to predict tumor volume of the lesion responsible for PHPT from preoperative clinical data.
methodsParticipants comprised patients with surgically treated PHPT who underwent initial surgery in our department between January 2000 and December 2021. The volume of parathyroid gland removed was used as the primary outcome and associations with preoperative clinical data were assessed by multivariable analysis.
resultsA positive correlation was identified between parathyroid tumor volume and both preoperative intact parathyroid hormone (PTH) (Spearman's r = 0.503) and calcium values (Spearman's r = 0.338). Data for intact PTH value and tumor volume were logarithmically transformed (ln-PTH = log-transformed intact PTH value; ln-volume = log-transformed tumor volume). Multiple regression analysis revealed male sex, ln-PTH and calcium values as significant predictors of ln-volume, with standardized regression coefficients of 0.213 (95% CI 0.103-0.323), 0.5018 (95% CI 0.4442-0559), and 0.322 (95% CI 0.0339-0.149), respectively. The adjusted R2 for this model is 0.320.
conclusionPreoperative serum intact PTH value is associated with tumor volume of the lesion responsible for PHPT. A rough estimation of the tumor size would provide responsible physicians with opportunities to add further imaging tests or plan appropriate surgical strategies.
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