ArticleJournal of veterinary research2024
Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus.
Article in Journal of veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Bovine leukaemia virus (BLV) is a Deltaretrovirus responsible for enzootic bovine leukosis, the most common neoplastic disease of cattle. It deregulates the immune system, favouring secondary infections and changes in the blood and lymphatic tissues. Blood homeostasis depends on functional haematopoietic stem cells (HSCs). Bone marrow is populated by these cells, which express CD34 Material and Methods: The HSCs were generated from the blood and lymphoid organs of cows infected with BLV and healthy control cows with immunomagnetic separation and anti-CD34 Results: The expression of IL-6, IL-12p70 and TNF-α in blood HSCs was higher in BLV Conclusion: Infection with BLV caused statistically significant differences in cytokine expression by HSC CD34
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