Evidence map›Paper›PMID 38525159›Full record

ArticleJournal of materials chemistry. C2024

NIR-II emissive donor-acceptor-donor fluorophores for dual fluorescence bioimaging and photothermal therapy applications.

Nicholas E Sparks, Cameron Smith, Terrence Stahl, Dhanush L Amarasekara, Christine Hamadani, Ethan Lambert, Sheng Wei Tang, Anuja Kulkarni, Blaine M Derbigny, Gaya S Dasanayake and 7 more

Abstract read
In one paragraph

Article in Journal of materials chemistry. C, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Dual-Module Near-Infrared Fluorophores Discovery System via Knowledge Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nicholas E SparksDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Cameron SmithDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0003-3072-028X
Terrence StahlDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Dhanush L AmarasekaraDepartment of Chemistry, Mississippi State University Mississippi State MS 39762 USA.
Christine HamadaniDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0003-4774-6777
Ethan LambertDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0001-6893-9071
Sheng Wei TangDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Anuja KulkarniDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Blaine M DerbignyDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Gaya S DasanayakeDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0002-2399-2458
George TaylorDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.
Maryam GhazalaDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.
Nathan I HammerDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0002-6221-2709
Alexander Y SokolovDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.ORCID https://orcid.org/0000-0003-2637-4134
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University Mississippi State MS 39762 USA.ORCID https://orcid.org/0000-0002-8993-2140
Eden E L TannerDepartment of Chemistry and Biochemistry, University of Mississippi University Oxford MS USA.ORCID https://orcid.org/0000-0002-7919-2249
Davita L WatkinsDepartment of Chemistry and Biochemistry, The Ohio State University Columbus Ohio 43210 USA watkins.891@osu.edu.ORCID https://orcid.org/0000-0002-0943-7220

Funding

Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR01AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2018 to 2022
$1.8M
Ionic Liquid-Coated NIR-II Polymer Conjugates as Targeted Brain TheranosticsR01EB034086 · NIBIB · OHIO STATE UNIVERSITY · PI WATKINS, DAVITA L. · 2022 to 2024
$1.6M
NIAID NIH HHS R01 AI139479NIBIB NIH HHS R01 EB034086
6 · The paper itself

Abstract

Fluorescence bioimaging with near-infrared II (NIR-II) emissive organic fluorophores has proven to be a viable noninvasive diagnostic technique. However, there is still the need for the development of fluorophores that possess increased stability as well as functionalities that impart stimuli responsiveness. Through strategic design, we can synthesize fluorophores that possess not only NIR-II optical profiles but also pH-sensitivity and the ability to generate heat upon irradiation. In this work, we employ a donor-acceptor-donor (D-A-D) design to synthesize a series of NIR-II fluorophores. Here we use thienothiadiazole (TTD) as the acceptor, 3-hexylthiophene (HexT) as the π-spacer and vary the alkyl amine donor units:

Identifiers

PMID38525159
PMCPMC10955863

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.