Evidence map›Paper›PMID 38525075›Full record

ArticleFrontiers in microbiology2024

The efficient synthesis and purification of 2'3'- cGAMP from

Rohan Kulkarni, Vijay Maranholkar, Nam Nguyen, Patrick C Cirino, Richard C Willson, Navin Varadarajan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Extracellular cGAMP in health and disease.Molecular biomedicine · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rohan KulkarniDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, United States.
Vijay MaranholkarDepartment of Biology and Biochemistry, University of Houston, Houston, TX, United States.
Nam NguyenDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, United States.
Patrick C CirinoDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, United States.
Richard C WillsonDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, United States.
Navin VaradarajanDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, United States.
University of Houston · US

Funding

MusIC: A multi-scale technology for integrating dynamic cellular function and molecular profilesR01GM143243 · NIGMS · UNIVERSITY OF HOUSTON · PI VARADARAJAN, NAVIN · 2021 to 2024
$1.8M
NIGMS NIH HHS R01 GM143243
6 · The paper itself

Abstract

Agonists of the stimulator of interferon genes (STING) pathway are being explored as potential immunotherapeutics for the treatment of cancer and as vaccine adjuvants for infectious diseases. Although chemical synthesis of 2'3' - cyclic Guanosine Monophosphate-Adenosine Monophosphate (cGAMP) is commercially feasible, the process results in low yields and utilizes organic solvents. To pursue an efficient and environmentally friendly process for the production of cGAMP, we focused on the recombinant production of cGAMP via a whole-cell biocatalysis platform utilizing the murine cyclic Guanosine monophosphate-Adenosine monophosphate synthase (mcGAS). In

Indexed as

2′3’-cGAMP productionEscherichia coli bacterial expressionlipopolysaccharide removalmurine cGAS enzymeSTING agonists

Identifiers

PMID38525075
PMCPMC10957790
OpenAlexW4392593490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.