ArticleEvolution letters2024
Intrinsic apoptosis is evolutionarily divergent among metazoans.
Article in Evolution letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Evolutionary trajectories, early diversification, and species-specific amplification of the metazoan inhibitor of apoptosis (IAP) repertoire.Molecular biology and evolution · 2026Article
- Apoptosis as an evolutionary battleground: pathogen pressure and the shaping of programmed cell death pathways.Frontiers in cell and developmental biology · 2026Review
- Engineering of the Caspase-3 Gene in Recombinant CHO Cells Caused More Apoptosis Resistance and enhanced Recombinant Protein Production Than the BAX Gene.Iranian biomedical journal · 2025Article
- Molecular Cell Biology of Apoptosis in Health and Disease.Advances in experimental medicine and biology · 2025Review
- Apoptosis-dependent head development during metamorphosis of the cnidarian Hydractinia symbiolongicarpus.Developmental biology · 2024Article
- PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters.Communications biology · 2024Article
- Evolution of Apoptotic Signaling Pathways Within Lophotrochozoans.Genome biology and evolution · 2024Article
- Cell death in bryophytes: emerging models to study core regulatory modules and conserved pathways.Annals of botany · 2024Review
- Induction of apoptosis by double-stranded RNA was present in the last common ancestor of cnidarian and bilaterian animals.PLoS pathogens · 2024Article
- Evolution of Caspases and the Invention of Pyroptosis.International journal of molecular sciences · 2024Review
- Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona.Scientific reports · 2024Article
- Apoptotic Factors Are Evolutionarily Conserved Since Mitochondrial Domestication.Genome biology and evolution · 2023Article
- Apoptotic gene loss in Cnidaria is associated with transition to parasitism.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is regulated cell death that depends on caspases. A specific initiator caspase is involved upstream of each apoptotic signaling pathway. Characterized in nematode, fly, and mammals, intrinsic apoptosis is considered to be ancestral, conserved among animals, and depends on shared initiators: caspase-9, Apaf-1 and Bcl-2. However, the biochemical role of mitochondria, the pivotal function of cytochrome c and the modality of caspase activation remain highly heterogeneous and hide profound molecular divergence among apoptotic pathways in animals. Uncovering the phylogenetic history of apoptotic actors, especially caspases, is crucial to shed light on the evolutionary history of intrinsic apoptosis. Here, we demonstrate with phylogenetic analyses that caspase-9, the fundamental key of intrinsic apoptosis, is deuterostome-specific, while caspase-2 is ancestral to bilaterians. Our analysis of Bcl-2 and Apaf-1 confirms heterogeneity in functional organization of apoptotic pathways in animals. Our results support emergence of distinct intrinsic apoptotic pathways during metazoan evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.