Evidence map›Paper›PMID 38524863›Full record

ArticleJournal of multidisciplinary healthcare2024

Nutritional Status Link with Polioseronegativity Among Children from Poliomyelitis Transmission High-Risk Area of the Democratic Republic of the Congo (DRC).

Guillaume N Mwamba, Michel Kabamba Nzaji, Nicole A Hoff, Patrick K Mukadi, Kamy Kaminye Musene, Sue K Gerber, Megan Halbrook, Cyrus Sinai, Trevon Fuller, Oscar Luboya Numbi and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of multidisciplinary healthcare, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Guillaume N MwambaDepartment of Public Health, Faculty of Medicine, University of Kamina, Kamina, Democratic Republic of the Congo.ORCID 0000-0003-0460-877X
Michel Kabamba NzajiDepartment of Public Health, Faculty of Medicine, University of Kamina, Kamina, Democratic Republic of the Congo.ORCID 0000-0003-3843-654X
Nicole A HoffDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Patrick K MukadiNational Institute of Biomedical Research (INRB), Ministry of Health, Kinshasa, Democratic Republic of the Congo.
Kamy Kaminye MuseneUCLA-DRC Health Research and Training Program, UCLA-DRC, Kinshasa, Democratic Republic of the Congo.
Sue K GerberPolio Eradication program, The Bill and Melinda Gates Foundation, Seattle, WA, 98109, USA.
Megan HalbrookDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Cyrus SinaiDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Trevon FullerDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Oscar Luboya NumbiFaculty of Medicine, University of Lubumbashi, Lubumbashi, 1825, Democratic Republic of the Congo.
Emile Okitolonda WemakoyDepartment of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Jean Jacques Muyembe TamfumNational Institute of Biomedical Research (INRB), Ministry of Health, Kinshasa, Democratic Republic of the Congo.
Dalau Nkamba MukadiDepartment of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Mala Ali Mapatano *Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Anne W Rimoin *Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Paul-Samson Lusamba Dikassa *Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
UCLA Health · USUniversity of Kinshasa · CDMinistry of Public Health · CDNational Institute of Biomedical Research · CDGates Foundation · USUniversity of Lubumbashi · CD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malnutrition is identified as a risk-factor for insufficient polioseroconversion in the context of a vaccine-derived polio virus (VDPV) outbreak prone region. To assess the prevalence of malnutrition and its link to poliovirus insufficient immunity, a cross-sectional household survey was conducted in the regions of Haut- Lomami and Tanganyika, DRC. Methods: In March 2018, we included 968 healthy children aged 6 to 59 months from eight out of 27 districts. Selection of study locations within these districts was done using a stratified random sampling method, where villages were chosen based on habitat characteristics identified from satellite images. Consent was obtained verbally in the preferred language of the participant (French or Swahili) by interviewers who received specific training for this task. Furthermore, participants contributed a dried blood spot sample, collected via finger prick. To assess malnutrition, we measured height and weight, applying WHO criteria to determine rates of underweight, wasting, and stunting. The assessment of immunity to poliovirus types 1, 2, and 3 through the detection of neutralizing antibodies was carried out at the CDC in Atlanta, USA. Results: Of the study population, we found 24.7% underweight, 54.8% stunted, and 15.4% wasted. With IC95%, underweight (OR=1.50; [1.11-2.03]), and the non-administration of vitamin A (OR=1.96; [1.52-2.54]) were significantly associated with seronegativity to polioserotype 1. Underweight (OR=1.64; [1.20-2.24]) and the non-administration of vitamin A (OR=1.55; [1.20-2.01]) were significantly associated with seronegativity to polioserotype 2. Underweight (OR=1.50; [1.11-2.03]), and the non-administration of vitamin A (OR=1.80. [1.38-2.35]) were significantly associated with seronegativity to polioserotype 3. Underweight (OR=1.68; IC95% [1.10-2.57]) and the non-administration of vitamin A (OR=1.82; IC95% [1.30-2.55]) were significantly associated with seronegativity to all polioserotypes. Conclusion: This study reveals a significant association between underweight and polioseronegativity in children. In order to reduce vaccine failures in high-risk areas, an integrated approach by vaccination and nutrition programs should be adopted.

Indexed as

childrenDRCmalnutritionpolioserotypeseronegativityunderweight

Identifiers

PMID38524863
PMCPMC10960541
OpenAlexW4392956915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.