Evidence map›Paper›PMID 38524776›Full record

ArticleOrganic process research & development2023

Kilo-Scale GMP Synthesis of Renewable Semisynthetic Vaccine-Grade Squalene.

Karl J Fisher, Laura Shirtcliff, Greg Buchanan, Andrew W Thompson, Frank X Woolard, Donald H LaMunyon, Jonathan L Marshall, Maya B Baranouskas, Rodger B Voelker, Jason S Lusk and 8 more

Open access · greenAbstract read
In one paragraph

Article in Organic process research & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Karl J FisherAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Laura ShirtcliffActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Greg BuchananAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Andrew W ThompsonAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Frank X WoolardAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Donald H LaMunyonActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Jonathan L MarshallActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Maya B BaranouskasActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Rodger B VoelkerActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Jason S LuskActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Charles E WellsActylis Eugene, 90 North Polk St., Suite 200, Eugene OR 97402, USA.
Raodoh MohamathAccess to Advanced Health Institute (AAHI), 1616 Eastlake Avenue East, Seattle, WA 98102, USA.
Robert KinseyAccess to Advanced Health Institute (AAHI), 1616 Eastlake Avenue East, Seattle, WA 98102, USA.
William R LykinsAccess to Advanced Health Institute (AAHI), 1616 Eastlake Avenue East, Seattle, WA 98102, USA.
Gabi Ramer-DenisoffAccess to Advanced Health Institute (AAHI), 1616 Eastlake Avenue East, Seattle, WA 98102, USA.
Christopher B FoxAccess to Advanced Health Institute (AAHI), 1616 Eastlake Avenue East, Seattle, WA 98102, USA.
Christopher J PaddonAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Derek McPheeAmyris Inc, 5885 Hollis St, Suite 100, Emeryville, CA 94608, USA.
Eugene Research Institute · USAmyris (United States) · USAccess to Advanced Health Institute

Funding

Engineering sustainable squalene analogues for novel vaccine adjuvant emulsionsR01AI135673 · NIAID · ACCESS TO ADVANCED HEALTH INSTITUTE · PI FOX, CHRISTOPHER B · 2018 to 2022
$4.1M
NIAID NIH HHS R01 AI135673
6 · The paper itself

Abstract

Emulsions of the triterpene squalene ((6

Indexed as

allylic sulfonefarnesenereductive desulfonylationsemi-synthesisSqualenethiourea inclusion complex crystallizationvaccine adjuvant

Identifiers

PMID38524776
PMCPMC10956619
OpenAlexW4388728573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.