Evidence map›Paper›PMID 38524762›Full record

ArticleISME communications2024

Bacterial diversity and chemical ecology of natural product-producing bacteria from Great Salt Lake sediment.

Elijah R Bring Horvath, William J Brazelton, Min Cheol Kim, Reiko Cullum, Matthew A Mulvey, William Fenical, Jaclyn M Winter

Open access · goldAbstract read
In one paragraph

Article in ISME communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. An extremophilicbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elijah R Bring HorvathDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, United States.ORCID https://orcid.org/0000-0002-8960-3558
William J BrazeltonSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, United States.ORCID https://orcid.org/0000-0003-0933-0148
Min Cheol KimCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States.ORCID https://orcid.org/0000-0002-9861-6131
Reiko CullumCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States.ORCID https://orcid.org/0000-0003-0884-1640
Matthew A MulveySchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, United States.ORCID https://orcid.org/0000-0002-6016-7510
William FenicalCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States.ORCID https://orcid.org/0000-0002-8955-1735
Jaclyn M WinterDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, United States.ORCID https://orcid.org/0000-0001-6273-5377
University of Utah · USScripps Institution of Oceanography · US

Funding

Genomics-Assisted Antibiotic Discovery from Unprecedented Microbes of the Great Salt LakeR01AI155694 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WINTER, JACLYN MARIE · 2021 to 2025
$3.1M
NIAID NIH HHS R01 AI155694
6 · The paper itself

Abstract

Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product-producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalog bacteria found in GSL, the Lake's microbiome is largely unexplored, and little to no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of two new Actinomycetota species, and provide the first survey of the natural product potential of GSL bacteria.

Indexed as

Actinomycetotachemical ecologyGreat Salt Lakehalophilesnatural products

Identifiers

PMID38524762
PMCPMC10960970
OpenAlexW4392757423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.