Evidence map›Paper›PMID 38524634›Full record

SynthesisFrontiers in endocrinology2024

Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.

Ahmad Mohd Faizal, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Oocyte-cumulus cell interaction: a key factor in early embryo development.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Expression ofInternational journal of reproductive biomedicine · 2025
    Article
  7. Observational
  8. Review
  9. Article
  10. A Comparative Analysis ofLife (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Electro-Metabolic Coupling of Cumulus-Oocyte Complex.International journal of molecular sciences · 2024
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ahmad Mohd FaizalDepartment of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Marjanu Hikmah EliasFaculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan, Malaysia.
Norazilah Mat JinDepartment of Obstetrics & Gynecology, Faculty of Medicine, Universiti Teknologi MARA, Jalan Hospital, Sungai Buloh, Selangor, Malaysia.
Muhammad Azrai AbuDepartment of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Saiful Effendi SyafruddinMedical Molecular Biology Institute, National University of Malaysia, Kuala Lumpur, Malaysia.
Ani Amelia ZainuddinDepartment of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Nao SuzukiDepartment of Obstetrics & Gynecology, St Marianna School of Medicine, Kawasaki, Japan.
Abdul Kadir Abdul KarimDepartment of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
National University of Malaysia · MYHospital Sungai Buloh · MYSt. Marianna University School of Medicine · JPUniversiti Sains Islam Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The leading indicator for successful outcomes in

Indexed as

Cumulus CellsSemenCyclooxygenase 2FemaleGene ExpressionHumansHyaluronan SynthasesIntercellular Signaling Peptides and ProteinsMaleOocytesCyclooxygenase 2GREM1 protein, humanHAS2 protein, humanHyaluronan SynthasesIntercellular Signaling Peptides and ProteinsPTGS2 protein, humancumulus cellsgene expressiongrem1HAS2oocytes development competencyPTGS2

Identifiers

PMID38524634
PMCPMC10957552
OpenAlexW4392592429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.