Evidence map›Paper›PMID 38524546›Full record

ArticleHeliyon2024

Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats.

Pavlina Andreeva-Gateva, Milen Hristov, Margarita Strokova-Stoilova, Natasha Ivanova, Zafer Sabit, Slavina Surcheva, Mihail Beliakov, Georgi Karakashev, Ivan Sukhov, Daria Belinskaya and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Pavlina Andreeva-GatevaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Milen HristovDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Margarita Strokova-StoilovaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Natasha IvanovaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Zafer SabitDepartment of Pathophysiology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Slavina SurchevaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
Mihail BeliakovLaboratory of Chemical Analytical Control and Biotesting, Research Institute of Hygiene, Occupational Pathology and Human Ecology, St Petersburg, Russia.
Georgi KarakashevLaboratory of Chemical Analytical Control and Biotesting, Research Institute of Hygiene, Occupational Pathology and Human Ecology, St Petersburg, Russia.
Ivan SukhovSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia.
Daria BelinskayaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia.
Natalia ShestakovaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia.
Medical University of Sofia · BGInstitute of Evolutionary Physiology and Biochemistry · RUSt. Petersburg Research Institute of Radiation Hygiene · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both peripheral neuropathy and depression can be viewed as neurodegeneration's consequences of diabetes, at least in part coexisting with or resulting from sodium-calcium dysbalance. This study aims to assess the therapeutic potential of the orally applied reverse-mode inhibitor of the sodium-calcium exchanger (NCX) KB-R7943 in the streptozotocin (STZ) diabetes model in rats. A pilot pharmacokinetic (PK) study with high-performance liquid chromatography with high-resolution tandem mass spectrometric detection revealed higher drug exposure (AUC), lower volume of distribution (Vd) and clearance (Cl), and faster decline of the plasma concentration (ƛ) in rats with diabetes vs. controls. Brain and heart accumulation and urinary excretion of the unmetabolized KB-R7943 at least 24 h were also demonstrated in all rats. However, heart and hippocampus KB-R7943 penetration (AUC

Indexed as

AmitriptylineBehavior testsDiabetic neuropathyKB-R7943Pharmacokinetics

Identifiers

PMID38524546
PMCPMC10958225
OpenAlexW4392697872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.