Evidence map›Paper›PMID 38524500›Full record

ArticleACS omega2024

Seq-RBPPred: Predicting RNA-Binding Proteins from Sequence.

Yuyao Yan, Wenran Li, Sijia Wang, Tao Huang

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuyao YanCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200021, China.ORCID https://orcid.org/0009-0000-1226-0879
Wenran LiCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200021, China.
Sijia WangCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200021, China.
Tao HuangCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-binding proteins (RBPs) can interact with RNAs to regulate RNA translation, modification, splicing, and other important biological processes. The accurate identification of RBPs is of paramount importance for gaining insights into the intricate mechanisms underlying organismal life activities. Traditional experimental methods to predict RBPs require a lot of time and money, so it is important to develop computational methods to predict RBPs. However, the existing approaches for RBP prediction still require further improvement due to unidentified RBPs in many species. In this study, we present Seq-RBPPred (predicting RBPs from sequence), a novel method that utilizes a comprehensive feature representation encompassing both biophysical properties and hidden-state features derived from protein sequences. In the results, comprehensive performance evaluations of Seq-RBPPred its superiority compare with state-of-the-art methods, yielding impressive performance including 0.922 for overall accuracy, 0.926 for sensitivity, 0.903 for specificity, and Matthew's correlation coefficient (MCC) of 0.757 as ascertained from the evaluation of the testing set. The data and code of Seq-RBPPred are available at https://github.com/yaoyao-11/Seq-RBPPred.

Identifiers

PMID38524500
PMCPMC10955590

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.