Evidence map›Paper›PMID 38524441›Full record

ArticleACS omega2024

Ultrasonic or Microwave Modified Continuous Flow Chemistry for the Synthesis of Tetrahydrocannabinol: Observing Effects of Various Solvents and Acids.

Giovanni A Ramirez, Tesfay T Tesfatsion, Maite L Docampo-Palacios, Ivan Cruces, Adam J Hellmann, Alex Okhovat, Monica K Pittiglio, Kyle P Ray, Westley Cruces

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Chemometric Optimization of BFChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giovanni A RamirezColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Tesfay T TesfatsionColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Maite L Docampo-PalaciosColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Ivan CrucesColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Adam J HellmannColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Alex OkhovatColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Monica K PittiglioColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Kyle P RayColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.
Westley CrucesColorado Chromatography Laboratories, 10505 S. Progress Way Unit 105, Parker, Colorado 80134, United States.ORCID https://orcid.org/0000-0003-3023-7626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method that utilizes a microwave or ultrasonic medium to produce major tetrahydrocannabinol isomers. This process produces excellent yields and minimal side products, which leads to more efficient large-scale production of the desired cannabinoids.

Identifiers

PMID38524441
PMCPMC10956408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.