Evidence map›Paper›PMID 38524222›Full record

ArticleOpen forum infectious diseases2024

Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants.

Laura Chen, Rebecca M Munday, Rashidul Haque, Dylan Duchen, Uma Nayak, Poonum Korpe, Alexander J Mentzer, Beth D Kirkpatrick, Genevieve L Wojcik, William A Petri and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07615842 (Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07615842 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2028Enrolled150ConditionsAntibiotic Resistance PreventionArmsAzithromycin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Prevalence of astrovirus-associated gastroenteritis among hospitalized pediatric patients in Asia: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Laura ChenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Rebecca M MundayDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-6534-972X
Rashidul HaqueEmerging Infections & Parasitology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Dylan DuchenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Uma NayakCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0003-0970-9262
Poonum KorpeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Alexander J MentzerThe Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-4502-2209
Beth D KirkpatrickDepartment of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
William A PetriDepartment of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-7268-1218
Priya DuggalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of Virginia · USCentre for Human Genetics · GBInternational Centre for Diarrhoeal Disease Research · BDUniversity of Vermont · US

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
STRUCTURE/FUNCTION OF E HISTOLYTICA ADHERENCE LECTINR01AI026649 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PETRI, WILLIAM A · 1989 to 2016
$6.1M
Role of CREM in Amebic Colitis and Inflammatory Bowel DiseaseR37AI026649 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2018 to 2026
$5.0M
Household Transmission of CryptosporidiumR01AI146123 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DUGGAL, PRIYA, KORPE, POONUM S. · 2019 to 2023
$3.5M
NIAID NIH HHS R01 AI026649NIAID NIH HHS R01 AI043596NIAID NIH HHS R01 AI146123NIAID NIH HHS R37 AI026649Wellcome Trust
6 · The paper itself

Abstract

Background: Astroviral infections commonly cause acute nonbacterial gastroenteritis in children globally. However, these infections often go undiagnosed outside of research settings. There is no treatment available for astrovirus, and Astroviridae strain diversity presents a challenge to potential vaccine development. Methods: To address our hypothesis that host genetic risk factors are associated with astrovirus disease susceptibility, we performed a genome-wide association study of astrovirus infection in the first year of life from children enrolled in 2 Bangladeshi birth cohorts. Results: We identified a novel region on chromosome 1 near the loricrin gene ( Conclusions: This study identified 2 significant host genetic regions that may influence astrovirus diarrhea susceptibility and should be considered in further studies.

Indexed as

AstrovirusdiarrheaGWAShost genetics

Identifiers

PMID38524222
PMCPMC10960603
OpenAlexW4392501071

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.