Evidence map›Paper›PMID 38524169›Full record

ArticleSleep and biological rhythms2024

Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model.

Öznur Özge Özcan, Burcu Çevreli, Arzu Temizyürek, Mesut Karahan, Muhsin Konuk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep and biological rhythms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Öznur Özge ÖzcanElectroneurophysiology, Vocational School of Health Sciences, Üsküdar University, Istanbul, Turkey.
Burcu ÇevreliNeuropsychopharmacology Practice and Research Center, Üsküdar University, Istanbul, Turkey.
Arzu TemizyürekDepartment of Physiology, Faculty of Medicine, Altınbaş University, Istanbul, Turkey.
Mesut KarahanMedical Laboratory Techniques, Vocational School of Health Sciences, Üsküdar University, Mimar Sinan, Selmani Pak, Üsküdar, 34672 Istanbul, Turkey.ORCID 0000-0002-8971-678X
Muhsin KonukDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University, Istanbul, Turkey.
Üsküdar University · TRAltınbaş University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sleep deprivation (SD) impairs pre-stimulus inhibition, but the effect of quetiapine (QET) remains largely unknown. Objective: This study aimed to investigate the behavioral and cognitive effects of QET in both naïve and sleep-deprived rats. Materials and methods: Seven groups ( Results: 72 h SD impaired PPI, reduced startle amplitude, and attenuated the PPI% at + 4 dB, + 8 dB, and + 16 dB prepulse intensities. 10 mg/kg short and long-term QET administration completely improved sensorimotor gating deficit, increased startle amplitude, and restored the impaired PPI% at + 4 dB, + 8 dB, and + 16 dB after 72 h SD in rats. Conclusion: Our results showed short- and long-term administration of QET improved sensorimotor gating deficit in 72 h SD. Further research is required for the etiology of insomnia and the dose-related behavioral effects of QET.

Indexed as

Prepulse inhibitionPsychosisQuetiapineRatSensorimotor gatingSleep deprivation

Identifiers

PMID38524169
PMCPMC10959884
OpenAlexW4389725588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.