Evidence map›Paper›PMID 38523663›Full record

ArticleJBMR plus2024

Structural differences contributing to sex-specific associations between FN BMD and whole-bone strength for adult White women and men.

Karl J Jepsen, Erin M R Bigelow, Robert W Goulet, Bonnie T Nolan, Michael A Casden, Kathryn Kennedy, Samantha Hertz, Chandan Kadur, Gregory A Clines, Aleda M Leis and 2 more

Abstract read
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. External validation of a novel HR-pQCT based fracture risk assessment tool (μFRAC) in a male cohort: the osteoporotic fractures in men (MrOS) study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: The Study of Muscle, Mobility and Aging (SOMMA).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Trajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karl J JepsenDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Erin M R BigelowDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Robert W GouletDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Bonnie T NolanDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Michael A CasdenDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Kathryn KennedyBiomedical Engineering, Marquette University, Milwaukee, WI 53201  United States.
Samantha HertzDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Chandan KadurDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Gregory A ClinesDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Aleda M LeisDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Carrie A Karvonen-GutierrezDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109  United States.
Todd L BredbennerDepartment of Mechanical and Aerospace Engineering, University of Colorado Colorado Springs, Colorado Springs, CO 80918  United States.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
CTSA K12 Program at the University of MichiganK12TR004374 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Leah Elizabeth Robinson · 2023 to 2026
$6.5M
THE ROLE OF BONE TRAIT COVARIATION IN VERTEBRAL FRACTURE RESISTANCER01AR064244 · NIAMS · UNIVERSITY OF COLORADO · PI BREDBENNER, TODD L · 2013 to 2017
$2.7M
Bone Robustness as a Biomarker of Skeletal Aging and FragilityR01AR065424 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JEPSEN, KARL J · 2014 to 2018
$2.4M
Changes in Periosteal and Endocortical Width Across the Menopausal TransitionR01AR068452 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JEPSEN, KARL J · 2018 to 2022
$2.2M
NCATS NIH HHS K12 TR004374NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR064244NIAMS NIH HHS R01 AR065424NIAMS NIH HHS R01 AR068452NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Hip areal BMD (aBMD) is widely used to identify individuals with increased fracture risk. Low aBMD indicates low strength, but this association differs by sex with men showing greater strength for a given aBMD than women. To better understand the structural basis giving rise to this sex-specific discrepancy, cadaveric proximal femurs from White female and male donors were imaged using nano-CT and loaded in a sideways fall configuration to assess strength. FN pseudoDXA images were generated to identify associations among structure, aBMD, and strength that differ by sex. Strength correlated significantly with pseudoDXA aBMD for females (

Indexed as

aginganalysis/quantitation of bone (DXA)analysis/quantitation of bone (other—strength)diseases and disorders of bone (osteoporosis)orthopedics (biomechanics)

Identifiers

PMID38523663
PMCPMC10958990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.