Evidence map›Paper›PMID 38523605›Full record

ArticleNature machine intelligence2023

Synthetic data accelerates the development of generalizable learning-based algorithms for X-ray image analysis.

Cong Gao, Benjamin D Killeen, Yicheng Hu, Robert B Grupp, Russell H Taylor, Mehran Armand, Mathias Unberath

Abstract read
In one paragraph

Article in Nature machine intelligence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Investigating robot control policy learning for autonomous x-ray-guided spine procedures.International journal of computer assisted radiology and surgery · 2026
    Article
  6. Article
  7. Article
  8. A Generative Foundation Model for Scalable Cytology Image Synthesis in AI-Powered Diagnostics.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. FluoroSAM: A Language-promptable Foundation Model for Flexible X-ray Image Segmentation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cong GaoDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6798-8381
Benjamin D KilleenDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-2511-7929
Yicheng HuDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Robert B GruppDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-3386-5839
Russell H TaylorDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6272-1100
Mehran ArmandDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Mathias UnberathDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0055-9950

Funding

Image-Guided Workstation and Tools for the Treatment of Bone DefectsR01EB016703 · NIBIB · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI ARMAND, MEHRAN · 2013 to 2022
$3.4M
Robotic System for Spinal Decompression and Interbody FusionR01AR080315 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI ARMAND, MEHRAN, JAIN, AMIT · 2022 to 2025
$1.7M
Robot-Assisted Femoroplasty with Intraoperative Biomechanical FeedbackR01EB023939 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ARMAND, MEHRAN · 2017 to 2020
$1.6M
Task-aware and Autonomous Robotic C-arm Servoing for Flouroscopy-guided InterventionsR21EB028505 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI UNBERATH, MATHIAS · 2020 to 2022
$629k
NIAMS NIH HHS R01 AR080315NIBIB NIH HHS R01 EB016703NIBIB NIH HHS R01 EB023939NIBIB NIH HHS R21 EB028505
6 · The paper itself

Abstract

Artificial intelligence (AI) now enables automated interpretation of medical images. However, AI's potential use for interventional image analysis remains largely untapped. This is because the post hoc analysis of data collected during live procedures has fundamental and practical limitations, including ethical considerations, expense, scalability, data integrity and a lack of ground truth. Here we demonstrate that creating realistic simulated images from human models is a viable alternative and complement to large-scale in situ data collection. We show that training AI image analysis models on realistically synthesized data, combined with contemporary domain generalization techniques, results in machine learning models that on real data perform comparably to models trained on a precisely matched real data training set. We find that our model transfer paradigm for X-ray image analysis, which we refer to as SyntheX, can even outperform real-data-trained models due to the effectiveness of training on a larger dataset. SyntheX provides an opportunity to markedly accelerate the conception, design and evaluation of X-ray-based intelligent systems. In addition, SyntheX provides the opportunity to test novel instrumentation, design complementary surgical approaches, and envision novel techniques that improve outcomes, save time or mitigate human error, free from the ethical and practical considerations of live human data collection.

Identifiers

PMID38523605
PMCPMC10959504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.