Evidence map›Paper›PMID 38523457›Full record

ArticleEnvironmental and molecular mutagenesis

Firefighting, per- and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk.

Margaret Quaid, Jaclyn M Goodrich, Miriam M Calkins, Judith M Graber, Derek Urwin, Jamie Gabriel, Alberto J Caban-Martinez, Rebekah L Petroff, Casey Grant, Shawn C Beitel and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental and molecular mutagenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Margaret QuaidDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.ORCID 0009-0001-6294-2429
Jaclyn M GoodrichDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.ORCID 0000-0002-8289-9253
Miriam M CalkinsNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
Judith M GraberDepartment of Biostatistics and Epidemiology, Rutgers the State University of New Jersey, Piscataway, New Jersey, USA.
Derek UrwinLos Angeles County Fire Department, Los Angeles, California, USA.ORCID 0000-0003-0055-2545
Jamie GabrielLos Angeles County Fire Department, Los Angeles, California, USA.
Alberto J Caban-MartinezDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Rebekah L PetroffDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Casey GrantFire Protection Research Foundation, Quincy, Massachusetts, USA.
Shawn C BeitelDepartment of Community, Environment and Policy, University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
Sally LittauDepartment of Community, Environment and Policy, University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
John J GulottaTucson Fire Department, Tucson, Arizona, USA.
Darin WallentineTucson Fire Department, Tucson, Arizona, USA.
Jeff HughesOrange County Fire Authority, Irvine, California, USA.
Jefferey L BurgessFire Protection Research Foundation, Quincy, Massachusetts, USA.
University of Michigan · USNational Fire Protection Association · USNew York City Fire Department · USUniversity of Arizona · USCenters for Disease Control and Prevention · USRutgers, The State University of New Jersey · USUniversity of California, Los Angeles · USUniversity of Miami · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
NIEHS NIH HHS P30 ES006694NIEHS NIH HHS P30 ES017885
6 · The paper itself

Abstract

Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures to many toxicants, including per- and polyfluoroalkyl substances (PFAS). This study assessed the association between firefighting as an occupation in general or PFAS serum levels, with DNA methylation. Only genomic regions previously linked to prostate cancer risk were selected for analysis: GSTP1, Alu repetitive elements, and the 8q24 chromosomal region. There were 444 male firefighters included in this study, with some analyses being conducted on fewer participants due to missingness. Statistical models were used to test associations between exposures and DNA methylation at CpG sites in the selected genomic regions. Exposure variables included proxies of cumulative firefighting exposures (incumbent versus academy status and years of firefighting experience) and biomarkers of PFAS exposures (serum concentrations of 9 PFAS). Proxies of cumulative exposures were associated with DNA methylation at 15 CpG sites and one region located within FAM83A (q-value <0.1). SbPFOA was associated with 19 CpG sites (q < 0.1), but due to low detection rates, this PFAS was modeled as detected versus not detected in serum. Overall, there is evidence that firefighting experience is associated with differential DNA methylation in prostate cancer risk loci, but this study did not find evidence that these differences are due to PFAS exposures specifically.

Indexed as

FluorocarbonsOccupational ExposureProstatic NeoplasmsDNADNA MethylationHumansMaleNeoplasm ProteinsDNAFAM83A protein, humanFluorocarbonsNeoplasm ProteinsDNA methylationenvironmental exposuresepigeneticsfirefightingoccupational health

Identifiers

PMID38523457
PMCPMC11006564
OpenAlexW4393152240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.