Evidence map›Paper›PMID 38523344›Full record

ArticleJournal of clinical research in pediatric endocrinology2024

Estrogen Receptor 1 Gene Polymorphism and its Association with Idiopathic Short Stature in a North Indian Population

Ravi Shankar Patel, Roshan Daniel, Chitra Bhardwaj, Anu Kumari, Pratibha Bawa, Ankita Tyagi, Devi Dayal, Anupriya Kaur, Inusha Panigrahi, Harvinder Kaur and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ravi Shankar PatelPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0009-0003-6849-4449
Roshan DanielPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0000-0001-6785-915X
Chitra BhardwajPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0000-0003-1385-4323
Anu KumariPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0009-0004-5257-9357
Pratibha BawaPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0009-0008-4107-8943
Ankita TyagiPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0009-0003-6220-2054
Devi DayalPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Pediatric Endocrinology Unit, Chandigarh, IndiaORCID 0000-0002-3279-6002
Anupriya KaurPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0000-0002-5307-5677
Inusha PanigrahiPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0000-0001-7375-9892
Harvinder KaurPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Child Growth and Anthropology Unit, Chandigarh, IndiaORCID 0000-0003-1991-0584
Priyanka SrivastavaPostgraduate Institute of Medical Education and Research (PGIMER), Advanced Pediatrics Centre, Genetic and Metabolic Unit, Chandigarh, IndiaORCID 0000-0003-1840-5711
Post Graduate Institute of Medical Education and Research · INGenetikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: In the hypothalamic-pituitary-gonadotrophin axis, estrogen plays a key role in the regulation of bone maturation and growth plate closure. This study was designed to explore the link between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 ( Methods: Four SNPs of Results: Fifty-two ISS patients were compared with 68 controls. A significant positive association was found between rs6557177 and rs543650 genotype and ISS susceptibility. The frequencies of the rs6557177 CC genotype [p=0.030; odds ratio (OR)=0.13; 95% confidence interval (CI): 0.01-1.10] and rs543650 genotype TT (p=0.043; OR=0.29; 95% CI: 0.09-0.92) were increased in the ISS group compared with controls. However, no significant correlation was observed between clinical parameters of patients and these SNPs. rs543650 showed strong LD with rs2234693 and rs9340799, similarly rs2234693 and rs9340799. Conclusion: Our study showed that the CC genotype at rs6557177 and TT genotype at rs543650 of

Indexed as

Estrogen Receptor alphaGrowth DisordersGenotypeHaplotypesHumansIndiaLinkage DisequilibriumPolymorphism, GeneticPolymorphism, Single NucleotideESR1 protein, humanEstrogen Receptor alphaestrogen receptor 1 geneGenotypehaplotypeidiopathic short staturelinkage disequilibriumsingle nucleotide polymorphism

Identifiers

PMID38523344
PMCPMC11590759
OpenAlexW4393155089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.