Evidence map›Paper›PMID 38523205›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Clinical features of adult patients with positive NMDAR-IgG coexisting with MOG-IgG.

Yuwei Dai, Yu Yuan, Fangfang Bi, Li Feng, Jing Li, Kai Hu, Si Chen, Qing Huang, Juan Li, Lili Long and 3 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuwei Dai *Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Yu Yuan *Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Fangfang BiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Li FengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Jing LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Kai HuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Si ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Qing HuangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Juan LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Lili LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Yuanyuan XieDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China. xieyy@qq.com.
Yanmin SongNational Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China. csuxysym@csu.edu.cn.ORCID http://orcid.org/0000-0003-3829-0683

Funding

Innovative Construction Foundation of Hunan Province 2022SK2042National Natural Science Foundation of China 82171454Natural Science Foundation of Hunan Province 2020JJ5914State Key Laboratory for Diagnosis and Treatment of Infectious Diseases z027001
6 · The paper itself

Abstract

introductionThis study was designed to analyze clinical and radiographic features of adult patients coexisting with NMDAR-IgG and MOG-IgG.

methodsEleven adult patients coexisting with NMDAR-IgG and MOG-IgG were collected from Xiangya Hospital, Central South University, between June 2017 and December 2021. Fifty-five patients with anti-NMDAR encephalitis and 49 with MOG-AD were served as controls.

resultsOnset age was 27 (IQR 20-34) years old. Seizures and psychotic symptoms were prominent symptoms. Ten of eleven patients presented abnormal T2/FLAIR hyperintensity, mainly involving the cortex, brainstem, and optic nerve. Compared with the NMDAR IgG ( +)/MOG IgG ( -) group, the NMDAR IgG ( +)/MOG IgG ( +) group showed more ataxia symptoms (27.3% vs. 3.6%, P = 0.037), while more T2/FLAIR hyperintensity lesions were found in the brainstem (54.5% vs. 7.3%, P < 0.001) and optic nerve (27.3% vs. 1.8%, P = 0.011) with more abnormal MRI patterns (90.9% vs. 41.8%, P = 0.003). In comparison with the NMDAR IgG ( -)/MOG IgG ( +) group, the NMDAR IgG ( +)/MOG IgG ( +) group had more seizures (72.7% vs. 24.5%, P = 0.007) and mental symptoms (45.5% vs. 0, P < 0.001). The NMDAR IgG ( +)/MOG IgG ( +) group tended to be treated with corticosteroids alone (63.6% vs. 20.0%, P = 0.009), more prone to recur (36.5% vs. 7.3%, P = 0.028) and lower mRS score (P = 0.036) at the last follow-up than pure anti-NMDAR encephalitis.

conclusionThe symptoms of the NMDAR IgG ( +)/MOG IgG ( +) group were more similar to anti-NMDAR encephalitis, while MRI patterns overlapped more with MOG-AD. Detecting both NMDAR-IgG and MOG-IgG maybe warranted in patients with atypical encephalitis symptoms and demyelinating lesions in infratentorial regions.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReceptors, N-Methyl-D-AspartateYoung AdultAutoantibodiesImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-AspartateAnti-NMDAR encephalitisMOG-abMOG-associated diseaseOverlapping demyelinating syndrome

Identifiers

PMID38523205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.