Evidence map›Paper›PMID 38523198›Full record

ArticleOral and maxillofacial surgery2024

Ozone infiltration as an adjunctive treatment to piezoelectric surgery in the management of medication-related osteonecrosis of the jaws: case series of 29 patients.

Funda Goker, Girolamo Donati, Francesco Gallo, Antonella Sparaco, Vito Rania, Alberto Busa, Francesco Grecchi, Emma Grecchi, Gianluca Colapinto, Massimo Del Fabbro

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In one paragraph

Article in Oral and maxillofacial surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Ozone therapy as an adjunctive strategy for MRONJ in oncology patients: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Funda GokerDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, MI, Italy.ORCID http://orcid.org/0000-0002-2354-361X
Girolamo DonatiDentistry Department, ASST Fatebenefratelli Sacco Hospital, Via Giovanni Battista Grassi, 74, Milan, Italy.
Francesco GalloIstituto Stomatologico Italiano a Milano, Via Pace, 21, Milano, 20122, Italy.
Antonella SparacoDentistry Department, ASST Fatebenefratelli Sacco Hospital, Via Giovanni Battista Grassi, 74, Milan, Italy.
Vito RaniaDentistry Department, ASST Fatebenefratelli Sacco Hospital, Via Giovanni Battista Grassi, 74, Milan, Italy.
Alberto BusaDentistry Department, ASST Fatebenefratelli Sacco Hospital, Via Giovanni Battista Grassi, 74, Milan, Italy.
Francesco GrecchiPrivate Clinic, Via G. Boccaccio, 34, Milano, 20123, Italy.
Emma GrecchiPrivate Clinic, Via G. Boccaccio, 34, Milano, 20123, Italy.
Gianluca ColapintoOral Med Care srl, Bitonto, Bari, Italy.
Massimo Del FabbroDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, MI, Italy. massimo.delfabbro@unimi.it.ORCID http://orcid.org/0000-0001-7144-0984
ASST Fatebenefratelli Sacco · ITUniversity of Milan · ITIRCCS Istituto Auxologico Italiano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMedication-related osteonecrosis of the jaws has been reported to be associated with bisphosphonate and RANKL inhibitor medications. This prospective clinical study aimed to assess the outcomes of pre-operative ozone infiltration therapy in patients with established MRONJ.

methodsThe treatment protocol for ozone applications were designed as 20 applications ozone infiltration therapy followed by surgical interventions of necrotic tissue debridement using piezoelectric surgery instruments. The evaluation of the results based on the clinical and radiologic specifications considering the necrotic lesion reduction and healing. The study included 31 lesions in 29 patients. The mean follow-up was 23.6 months.

results25 lesions out of 31 healed totally without any remissions. The outcomes were not affected by any variables such as gender, age, type of pharmacological treatment, lesion location, and MRONJ staging. The statistically significant results were found among the clinical condition of the patients (p = 0.01) and administration route of medications (p = 0.004). Healing was significantly less in patients that received intra-vascular administrations. Clinical conditions of the patients were divided as osteoporosis, oncologic, and arthritis. Significantly better results were obtained in osteoporosis patients. 38% of the population experienced spontaneous sequestration with signs of improvements and the surgical interventions were canceled. According to the results, total healing of MRONJ lesions was seen in 79% patients (81% lesions).

conclusionOzone therapy and debridement with Piezoelectric surgery can be considered as a safe and beneficial adjunctive treatment alternative for osteonecrosis lesions in cases of established MRONJ.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawDebridementOzonePiezosurgeryAdultAgedAged, 80 and overBone Density Conservation AgentsCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesBone Density Conservation AgentsOzoneMRONJMRONJ treatmentOxygen therapyOzone therapyPiezoelectric surgery

Identifiers

PMID38523198
OpenAlexW4393153898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.