Evidence map›Paper›PMID 38523140›Full record

ReviewNature reviews. Disease primers2024

Multidrug-resistant tuberculosis.

Keertan Dheda, Fuad Mirzayev, Daniela Maria Cirillo, Zarir Udwadia, Kelly E Dooley, Kwok-Chiu Chang, Shaheed Vally Omar, Anja Reuter, Tahlia Perumal, C Robert Horsburgh and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Disease primers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
69.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 180 citations in OpenAlex.

  1. Trial
  2. Isotopic tracing inVirulence · 2026
    Article
  3. Over-expression, purification, and kinetic analysis ofJournal of enzyme inhibition and medicinal chemistry · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. ComparativeMicrobiology spectrum · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Gemifloxacin resistance inMicrobiology spectrum · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 7 countries.

Keertan DhedaCentre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa. keertan.dheda@uct.ac.za.ORCID http://orcid.org/0000-0001-7709-5341
Fuad MirzayevGlobal Tuberculosis Programme, WHO, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6658-0325
Daniela Maria CirilloEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute Milan, Milan, Italy.
Zarir UdwadiaDepartment of Pulmonology, Hinduja Hospital & Research Center, Mumbai, India.
Kelly E DooleyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kwok-Chiu ChangTuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, SAR, China.ORCID http://orcid.org/0000-0002-3682-5069
Shaheed Vally OmarCentre for Tuberculosis, National & WHO Supranational TB Reference Laboratory, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa.
Anja ReuterSentinel Project on Paediatric Drug-Resistant Tuberculosis, Boston, MA, USA.
Tahlia PerumalCentre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.
C Robert HorsburghDepartment of Epidemiology, Boston University Schools of Public Health and Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6838-7895
Megan MurrayDepartment of Epidemiology, Harvard Medical School, Boston, MA, USA.
Christoph LangeDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.
University of Cape Town · ZAAmerican Sentinel University · USBaylor College of Medicine · USBoston University · USDepartment of Health · CNHarvard University · USNational Health Laboratory Service · ZAP. D. Hinduja Hospital and Medical Research Centre · INVanderbilt University Medical Center · USVita-Salute San Raffaele University · IT

Funding

Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chandravanu Dash · 2015 to 2026
$27.5M
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI FORTUNE, SARAH · 2019 to 2023
$14.6M
Mentoring Investigators in HIV and Tuberculosis Therapeutics ResearchK24AI150349 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOOLEY, KELLY E. · 2020 to 2025
$789k
NIAID NIH HHS K24 AI150349NIAID NIH HHS U19 AI142793World Health Organization 001
6 · The paper itself

Abstract

Tuberculosis (TB) remains the foremost cause of death by an infectious disease globally. Multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB; resistance to rifampicin and isoniazid, or rifampicin alone) is a burgeoning public health challenge in several parts of the world, and especially Eastern Europe, Russia, Asia and sub-Saharan Africa. Pre-extensively drug-resistant TB (pre-XDR-TB) refers to MDR/RR-TB that is also resistant to a fluoroquinolone, and extensively drug-resistant TB (XDR-TB) isolates are additionally resistant to other key drugs such as bedaquiline and/or linezolid. Collectively, these subgroups are referred to as drug-resistant TB (DR-TB). All forms of DR-TB can be as transmissible as rifampicin-susceptible TB; however, it is more difficult to diagnose, is associated with higher mortality and morbidity, and higher rates of post-TB lung damage. The various forms of DR-TB often consume >50% of national TB budgets despite comprising <5-10% of the total TB case-load. The past decade has seen a dramatic change in the DR-TB treatment landscape with the introduction of new diagnostics and therapeutic agents. However, there is limited guidance on understanding and managing various aspects of this complex entity, including the pathogenesis, transmission, diagnosis, management and prevention of MDR-TB and XDR-TB, especially at the primary care physician level.

Indexed as

Extensively Drug-Resistant TuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsHumansIsoniazidRifampinAntitubercular AgentsIsoniazidRifampin

Identifiers

PMID38523140
PMCPMC13335523
OpenAlexW4393131355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.