Evidence map›Paper›PMID 38522762›Full record

ArticlePharmacological research2024

Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.

Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Mechanistic elucidation ofJournal of ginseng research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Yongfeng CaiVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Yaqi ZhouState Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Qiuhua YangVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Jiean XuVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Qingen DaState Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Qian MaVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Dingwei ZhaoVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Tammy LuEmory University, Atlanta, GA 30322, USA.
Ha Won KimVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
David FultonVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Xuejun JiangState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Science, Beijing, 100101, China.
Neal L WeintraubVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Kunzhe DongImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Suowen XuDepartment of Endocrinology, the First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230001, China.
Mei HongState Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address: meihong@pkusz.edu.cn.
Zhiping LiuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China. Electronic address: zhiping0414@163.com.
Yuqing HuoVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. Electronic address: yhuo@augusta.edu.
Augusta University · USPeking University · CNAugusta University Health · USEmory University · USInstitute of Microbiology · CNJinan University · CNUniversity of Science and Technology of China · CN

Funding

Myeloid glycolysis in pathological ocular angiogenesisR01EY030500 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2019 to 2023
$2.6M
Adenosine receptor 2A in subretinal fibrosisR01EY033737 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Ruth B Caldwell, YUQING HUO · 2022 to 2026
$2.1M
"Myeloid PFKFB3 in subretinal fibrosis"R01EY033369 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2022 to 2025
$1.6M
American Heart Association-American Stroke Association 19TPA34910043American Heart Association-American Stroke Association 23POST1026238American Heart Association-American Stroke Association 968801NEI NIH HHS R01 EY030500NEI NIH HHS R01 EY033369NEI NIH HHS R01 EY033737
6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiating factors of atherosclerosis. Recently, we reported that endothelial adenosine receptor 2 A (ADORA2A), a G protein-coupled receptor (GPCR), plays critical roles in neovascularization disease and cerebrovascular disease. However, the precise role of endothelial ADORA2A in atherosclerosis is still not fully understood. Here, we showed that ADORA2A expression was markedly increased in the aortic endothelium of humans with atherosclerosis or Apoe

Indexed as

AtherosclerosisCyclic AMP Response Element-Binding ProteinEpithelial-Mesenchymal TransitionMice, Inbred C57BLReceptor, Adenosine A2AReceptor, Transforming Growth Factor-beta Type IAdenosine A2 Receptor AntagonistsAnimalsCells, CulturedEndothelial CellsHumansMaleMiceMice, KnockoutSignal TransductionAdenosine A2 Receptor AntagonistsADORA2A protein, humanAdora2a protein, mouseCREB1 protein, humanCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinReceptor, Adenosine A2AReceptor, Transforming Growth Factor-beta Type ITGFBR1 protein, humanTgfbr1 protein, mouseAdenosine receptor 2 AALK5AtherosclerosisCREBEndothelial to mesenchymal transition

Identifiers

PMID38522762
PMCPMC12674621
OpenAlexW4393123638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.