Evidence map›Paper›PMID 38522749›Full record

ArticleJournal of lipid research2024

Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis.

Claire E Kitzmiller, Tan-Yun Cheng, Jacques Prandi, Ian L Sparks, D Branch Moody, Yasu S Morita

Open access · goldAbstract read
In one paragraph

Article in Journal of lipid research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Rv3839-Rv3840 links the endogenous heme biosynthesis pathway withbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. EngineeredJournal for immunotherapy of cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Claire E KitzmillerDepartment of Microbiology, University of Massachusetts, Amherst, MA, USA.
Tan-Yun ChengDivision of Rheumatology, Immunity and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jacques PrandiInstitut de Pharmacologie et de Biologie Structurale, CNRS, UPS, Université de Toulouse, Toulouse, France.
Ian L SparksDepartment of Microbiology, University of Massachusetts, Amherst, MA, USA.
D Branch MoodyDivision of Rheumatology, Immunity and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yasu S MoritaDepartment of Microbiology, University of Massachusetts, Amherst, MA, USA. Electronic address: ymorita@umass.edu.
University of Massachusetts Amherst · USBrigham and Women's Hospital · USCentre National de la Recherche Scientifique · FR

Funding

Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)U19AI162584 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI RHEE, KYU Y · 2021 to 2025
$13.5M
T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial PathogensR01AI165573 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2022 to 2025
$3.0M
Cell envelope integrity in mycobacteria: interplay of lipoglycans, peptidoglycan, and capsular polysaccharidesR21AI168791 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S · 2023 to 2024
$420k
NIAID NIH HHS R01 AI049313NIAID NIH HHS R01 AI165573NIAID NIH HHS R21 AI168791NIAID NIH HHS U19 AI162584
6 · The paper itself

Abstract

Mycobacterial plasma membrane, together with the peptidoglycan-arabinogalactan cell wall and waxy outer membrane, creates a robust permeability barrier against xenobiotics. The fact that several antituberculosis drugs target plasma membrane-embedded enzymes underscores the importance of the plasma membrane in bacterial physiology and pathogenesis. Nevertheless, its accurate phospholipid composition remains undefined, with conflicting reports on the abundance of phosphatidylinositol mannosides (PIMs), physiologically important glycolipids evolutionarily conserved among mycobacteria and related bacteria. Some studies indicate cardiolipin, phosphatidylethanolamine, and phosphatidylinositol as dominant structural phospholipids. Conversely, some suggest PIMs dominate the plasma membrane. A striking example of the latter is the use of reverse micelle extraction, showing diacyl phosphatidylinositol dimannoside (Ac

Indexed as

Mycobacterium smegmatisPhosphatidylinositolsCell MembraneDetergentsDetergentsphosphatidylinositol dimannosidePhosphatidylinositolsbiosynthesischemical synthesisglycolipidsmembrane fluiditymetabolismphospholipidsreverse micelle extractionstress response

Identifiers

PMID38522749
PMCPMC11269278
OpenAlexW4393132097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.