Evidence map›Paper›PMID 38522472›Full record

ArticleInternational wound journal2024

Topical oxygen therapy and singlet oxygen in wound healing: A scoping review.

Martina Sýkorová, Christine Joy Moffatt, Neil Stentiford, Ewa Anna Burian, Sasagaki Katsuhiro, Yang Wei

Registry-linked trialOpen access · goldAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07370051 (Effect of Topical Oxygen and LED Light Therapy on Nipple Crack), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07370051 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Topical Oxygen and LED Light Therapy on Nipple Crack: A Randomized Controlled Trial

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2026 to 2027Enrolled51ConditionsBreastfeeding, Newborn Infant, Midwifery, BreastArmsTopical oxygen therapy, LED light therapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Martina SýkorováSkin Integrity Research Group, School of Health Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK.ORCID https://orcid.org/0000-0002-2579-5888
Christine Joy MoffattThe Institute of Care Excellence, Nottingham University Hospitals NHS Trust, City Hospital, Nottingham, UK.
Neil StentifordSOE Health Ltd, Nottingham, UK.
Ewa Anna BurianDepartment of Dermato-Venereology and Wound Healing Center, Bispebjerg Hospital, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-0630-2694
Sasagaki KatsuhiroMedical Technologies Innovation Facility, Engineering Department, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Yang WeiMedical Technologies Innovation Facility, Engineering Department, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Nottingham Trent University · GBBispebjerg Hospital · DKNottingham University Hospitals NHS Trust · GBUniversity of Nottingham · GB

Funding

SOE Health LtdUniversity of Nottingham
6 · The paper itself

Abstract

The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under-researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013-2023) with 32 (65.3%) published in the past 5 years (2018-2023). Eight of the studies were systematic reviews and/or meta-analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio-properties.

Indexed as

Diabetic FootSinglet OxygenCohort StudiesHumansOxygenWound HealingOxygenSinglet Oxygenleg ulceroxygensinglet oxygentopical oxygen therapywound healing

Identifiers

PMID38522472
PMCPMC10961185
OpenAlexW4394765426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.