Evidence map›Paper›PMID 38522372›Full record

ArticlePsychoneuroendocrinology2024

Stress biomarkers and child development in young children in Bangladesh.

Zachary Butzin-Dozier, Andrew N Mertens, Sophia T Tan, Douglas A Granger, Helen O Pitchik, Dora Il'yasova, Fahmida Tofail, Md Ziaur Rahman, Ivan Spasojevic, Idan Shalev and 23 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. [Association between umbilical cord blood proteome and early infant neurodevelopmental risk].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 8 institutions in 2 countries.

Zachary Butzin-DozierSchool of Public Health, University of California, Berkeley, CA, USA.
Andrew N MertensSchool of Public Health, University of California, Berkeley, CA, USA.
Sophia T TanDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Douglas A GrangerInstitute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helen O PitchikSchool of Public Health, University of California, Berkeley, CA, USA.
Dora Il'yasovaDuke University School of Medicine, Durham, NC, USA.
Fahmida TofailInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Ziaur RahmanInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Ivan SpasojevicDuke University School of Medicine, Durham, NC, USA.
Idan ShalevDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Shahjahan AliInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Mohammed Rabiul KarimInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Sunny ShahriarInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Syeda Luthfa FamidaInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Gabrielle ShumanSchool of Public Health, University of California, Berkeley, CA, USA.
Abul K ShoabInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Salma AktherInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Saheen HossenInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Palash MutsuddiInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Mahbubur RahmanInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Leanne UnicombInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Kishor K DasInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Liying YanEpigenDx, Inc., Hopkinton, MA, USA.
Ann MeyerEpigenDx, Inc., Hopkinton, MA, USA.
Christine P StewartDepartment of Nutrition, University of California, Davis, CA, USA.
Alan E HubbardSchool of Public Health, University of California, Berkeley, CA, USA.
Ruchira Tabassum NavedInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Kausar ParvinInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Mahfuz Al MamunInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Stephen P LubyDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
John M ColfordSchool of Public Health, University of California, Berkeley, CA, USA.
Lia C H FernaldSchool of Public Health, University of California, Berkeley, CA, USA.
Audrie LinDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. Electronic address: audrielin@ucsc.edu.
International Centre for Diarrhoeal Disease Research · BDUniversity of California, Berkeley · USBerkeley Public Health Division · USDuke University · USBioscience Research · USPennsylvania State University · USStanford University · USUniversity of California, Davis · US

Funding

A bench to population epidemiologic approach to investigating the effects of antenatal stress and inflammation on child gut inflammation, growth, and developmentK01AI136885 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LIN, AUDRIE · 2019 to 2023
$648k
NCI NIH HHS P30-CA014236–47NIAID NIH HHS K01 AI136885
6 · The paper itself

Abstract

backgroundHundreds of millions of children in low- and middle-income countries are exposed to chronic stressors, such as poverty, poor sanitation and hygiene, and sub-optimal nutrition. These stressors can have physiological consequences for children and may ultimately have detrimental effects on child development. This study explores associations between biological measures of chronic stress in early life and developmental outcomes in a large cohort of young children living in rural Bangladesh.

methodsWe assessed physiologic measures of stress in the first two years of life using measures of the hypothalamic-pituitary-adrenal (HPA) axis (salivary cortisol and glucocorticoid receptor gene methylation), the sympathetic-adrenal-medullary (SAM) system (salivary alpha-amylase, heart rate, and blood pressure), and oxidative status (F2-isoprostanes). We assessed child development in the first two years of life with the MacArthur-Bates Communicative Development Inventories (CDI), the WHO gross motor milestones, and the Extended Ages and Stages Questionnaire (EASQ). We compared development outcomes of children at the 75th and 25th percentiles of stress biomarker distributions while adjusting for potential confounders using generalized additive models, which are statistical models where the outcome is predicted by a potentially non-linear function of predictor variables.

resultsWe analyzed data from 684 children (49% female) at both 14 and 28 months of age; we included an additional 765 children at 28 months of age. We detected a significant relationship between HPA axis activity and child development, where increased HPA axis activity was associated with poor development outcomes. Specifically, we found that cortisol reactivity (coefficient -0.15, 95% CI (-0.29, -0.01)) and post-stressor levels (coefficient -0.12, 95% CI (-0.24, -0.01)) were associated with CDI comprehension score, post-stressor cortisol was associated with combined EASQ score (coefficient -0.22, 95% CI (-0.41, -0.04), and overall glucocorticoid receptor methylation was associated with CDI expression score (coefficient -0.09, 95% CI (-0.17, -0.01)). We did not detect a significant relationship between SAM activity or oxidative status and child development.

conclusionsOur observations reveal associations between the physiological evidence of stress in the HPA axis with developmental status in early childhood. These findings add to the existing evidence exploring the developmental consequences of early life stress.

Indexed as

Child DevelopmentHydrocortisoneBangladeshBiomarkersChildChild, PreschoolFemaleHumansHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemReceptors, GlucocorticoidSalivaStress, PsychologicalBiomarkersHydrocortisoneReceptors, GlucocorticoidAlpha-amylaseChild developmentCortisolStress

Identifiers

PMID38522372
PMCPMC11157411
OpenAlexW4392639380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.