Evidence map›Paper›PMID 38522064›Full record

ArticleBiochemical genetics2025

Potential Impact of SOD2 (rs4880; p.Val16Ala) Variant with the Susceptibility for Childhood Bronchial Asthma.

Nahla H Anber, Hanaa Elsayed Ahmed Shahin, Heba K Badawy, Enas A Oraby, Sameh A Mohammed, Esraa Ibrahim A Shaaban, Zeinab Rizk Attia, Shereen Mohamed, Mona Farag Shabana, Mohamed Adel El-Eshmawy and 4 more

Abstract read
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Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 3 countries.

Nahla H AnberDepartment of Biochemistry, Emergency Hospital, Mansoura University, Mansoura, Egypt.
Hanaa Elsayed Ahmed ShahinNursing Department, College of Applied Medial Sciences, Jouf University, ElQurayyat, Saudi Arabia.
Heba K BadawyDepartment of Biochemistry, Faculty of Pharmacy, Sinai University, Arish, Sinai, Egypt.
Enas A OrabyDepartment of Biochemistry, Emergency Hospital, Mansoura University, Mansoura, Egypt.
Sameh A MohammedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Esraa Ibrahim A ShaabanDepartment of Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Zeinab Rizk AttiaMansoura University Children's Hospital, Mansoura University, Mansoura, Egypt.
Shereen MohamedPediatric Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt.
Mona Farag ShabanaDepartment of Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mohamed Adel El-EshmawyClinical Pathology Department, Mansoura University Hospital, Mansoura University, Mansoura, Egypt.
Riham ElsayedDepartment of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Afaf M ElsaidGenetic Unit, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt.
Adel I AlalawyDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Rami M ElshazliBiochemistry and Molecular Genetics Unit, Department of Basic Sciences, Faculty of Physical Therapy, Horus University - Egypt, New Damietta, Egypt. Relshazly@horus.edu.eg.
Mansoura University Hospital · EGChildren's Hospital Mansoura University · EGBeni-Suef University · EGCairo University · EGDamietta University · EGFayoum University · EGJouf University · SAMansoura University · EGNagoya City University · JPSinai University · EGUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a sophisticated situation that orignates from the accumulation of reactive free radicals within cellular compartments. The antioxidant mechanism of the MnSOD enzyme facilitates the removal of these lethal oxygen species from cellular components. The main goal of this pertained work is to study the contribution of the SOD2 (rs4880; p.Val16Ala) variant to the development of bronchial asthma among children. The study's design was carried out based on a total of 254 participants including 127 asthmatic children (91 atopic and 36 non-atopic) along with 127 unrelated healthy controls. Allelic discrimination analysis was executed using the T-ARMS-PCR protocol. This potential variant conferred a significant association with decreased risk of bronchial asthmatic children under allelic (OR = 0.56, P-value = 0.002), recessive (OR = 0.32, P-value = 0.011), and dominant (OR = 0.51, P-value = 0.040) models. Additionally, atopic and non-atopic asthmatic children indicated a protection against bronchial asthma development under allelic, and dominant models (p-value < 0.05). Our findings suggested that the SOD2*rs4880 variant was correlated with decreased risk of childhood bronchial asthma.

Indexed as

AsthmaGenetic Predisposition to DiseasePolymorphism, Single NucleotideSuperoxide DismutaseAllelesCase-Control StudiesChildFemaleHumansMaleSuperoxide Dismutase 2Superoxide DismutaseSuperoxide Dismutase 2Oxidative stress and Bronchial asthmaSOD2*rs4880SOD2*Val16Ala

Identifiers

PMID38522064
OpenAlexW4393131131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.