Evidence map›Paper›PMID 38522027›Full record

ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2024

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

Matthew J Dalby, Vanja Pekovic-Vaughan, Daryl P Shanley, Joe Swift, Lisa J White, Elizabeth G Canty-Laird

Abstract read
In one paragraph

Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew J DalbyCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-0528-3359
Vanja Pekovic-VaughanDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, William Henry Duncan Building, University of Liverpool, Liverpool, UK.ORCID 0000-0002-7876-652X
Daryl P ShanleyCampus for Ageing and Vitality, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.ORCID 0000-0003-3096-6386
Joe SwiftWellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.ORCID 0000-0002-5039-9094
Lisa J WhiteSchool of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, UK.ORCID 0000-0003-0571-999X
Elizabeth G Canty-LairdDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, William Henry Duncan Building, University of Liverpool, Liverpool, UK.ORCID 0000-0001-5041-1316

Funding

UK Research and Innovation BB/W018314/1
6 · The paper itself

Abstract

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three-dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age-associated pathology. The ECM 'Ageing Across the Life Course' interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field.

Indexed as

AgingExtracellular MatrixAnimalsHumansUnited Kingdomageingbiophysicschronobiologyextracellular matrixmodel systems

Identifiers

PMID38522027
PMCPMC11476481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.