Evidence map›Paper›PMID 38521968›Full record

ArticleCancer biology & therapy2024

The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies.

Hannah M Hicks, Veronica L Nassar, Jane Lund, Madison M Rose, Rebecca E Schweppe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hannah M HicksDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-5618-7263
Veronica L NassarDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Jane LundDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Madison M RoseDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-3827-3330
Rebecca E SchweppeDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-7502-0151
University of Colorado Denver · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Training in Translational Research of Lung, Head and Neck CancerT32CA174648 · NCI · UNIVERSITY OF COLORADO DENVER · PI KARAM, SANA D · 2013 to 2022
$4.2M
Targeting FAK and Src in thyroid cancerR01CA222299 · NCI · UNIVERSITY OF COLORADO DENVER · PI SCHWEPPE, REBECCA ELIZABETH · 2018 to 2022
$2.6M
The Regulation of Apoptosis by Cooperative Src and MAPK Signaling in Thyroid CancerF31CA247211 · NCI · UNIVERSITY OF COLORADO DENVER · PI ROSE, MADISON MARIAH KING · 2020 to 2022
$111k
The role of an invasive phenotype in promoting resistance to MAPK-directed therapies in thyroid cancerF31CA257079 · NCI · UNIVERSITY OF COLORADO DENVER · PI HICKS, HANNAH M · 2021 to 2022
$67k
NCI NIH HHS F31 CA247211NCI NIH HHS F31 CA257079NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA222299NCI NIH HHS T32 CA174648
6 · The paper itself

Abstract

Thyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in

Indexed as

Proto-Oncogene Proteins B-rafThyroid NeoplasmsAurora KinasesCell Line, TumorHumansMAP Kinase Signaling SystemMutationProtein Kinase InhibitorsAurora KinasesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafAurora KinaseBRAFdrug resistanceERK1/2MAP kinasethyroid cancer

Identifiers

PMID38521968
PMCPMC10962586
OpenAlexW4393131153

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.