Evidence map›Paper›PMID 38521786›Full record

ArticleNature communications2024

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis.

Hideaki T Matsubayashi, Jack Mountain, Nozomi Takahashi, Abhijit Deb Roy, Tony Yao, Amy F Peterson, Cristian Saez Gonzalez, Ibuki Kawamata, Takanari Inoue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hideaki T MatsubayashiDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. hideaki.matsubayashi.e1@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-0198-4465
Jack MountainDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nozomi TakahashiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Tohoku, Japan.
Abhijit Deb RoyDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Tony YaoDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0003-6375-3712
Amy F PetersonDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Cristian Saez GonzalezDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4846-3680
Ibuki KawamataDepartment of Robotics, Tohoku University, Tohoku, Japan.ORCID http://orcid.org/0000-0002-1955-8827
Takanari InoueDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. jctinoue@jhmi.edu.ORCID http://orcid.org/0000-0002-7957-7624
Johns Hopkins University · USTohoku University · JP

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Decoding dynamic interplay between signaling and membranes in chemotaxis bymolecular actuatorsR35GM149329 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2023 to 2026
$2.8M
Feedback and Crosstalk in Eukaryotic ChemotaxisR01GM123130 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI INOUE, TAKANARI · 2018 to 2021
$1.5M
ActuAtor, a molecular tool for generating force in living cellsR01GM136858 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI INOUE, TAKANARI · 2020 to 2022
$983k
NIGMS NIH HHS R01 GM123130NIGMS NIH HHS R01 GM136858NIGMS NIH HHS R35 GM149329NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Class IA phosphoinositide 3-kinase (PI3K) galvanizes fundamental cellular processes such as migration, proliferation, and differentiation. To enable these multifaceted roles, the catalytic subunit p110 utilizes the multi-domain, regulatory subunit p85 through its inter SH2 domain (iSH2). In cell migration, its product PI(3,4,5)P

Indexed as

Phosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesCell MovementEndocytosissrc Homology DomainsPhosphatidylinositol 3-KinasePhosphatidylinositol 3-Kinases

Identifiers

PMID38521786
PMCPMC10960865
OpenAlexW4393114092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.