Evidence map›Paper›PMID 38521150›Full record

ArticleNeuropsychologia2024

Bypassing input to V1 in visual awareness: A TMS-EROS investigation.

Ramisha S Knight, Tao Chen, Evan G Center, Gabriele Gratton, Monica Fabiani, Silvia Savazzi, Chiara Mazzi, Diane M Beck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ramisha S KnightBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Aptima, Inc. 2555 University Blvd, Fairborn, OH, USA.
Tao ChenBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Department of Psychology, University of Illinois. 601 E John Street, Champaign, IL, USA. Electronic address: taoc2@illinois.edu.
Evan G CenterBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Department of Psychology, University of Illinois. 601 E John Street, Champaign, IL, USA; Center for Ubiquitous Computing, University of Oulu, Oulu, Finland.
Gabriele GrattonBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Department of Psychology, University of Illinois. 601 E John Street, Champaign, IL, USA.
Monica FabianiBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Department of Psychology, University of Illinois. 601 E John Street, Champaign, IL, USA.
Silvia SavazziPerception and Awareness (PandA) Lab, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Chiara MazziPerception and Awareness (PandA) Lab, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Diane M BeckBeckman Institute, University of Illinois.405 N Mathews Avenue, Urbana, IL, USA; Department of Psychology, University of Illinois. 601 E John Street, Champaign, IL, USA. Electronic address: dmbeck@illinois.edu.

Funding

Investigating Frontoparietal and Occipitotemporal Contributions to AwarenessR01EY022605 · NEI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BECK, DIANE MARIE · 2013 to 2016
$1.3M
NEI NIH HHS R01 EY022605
6 · The paper itself

Abstract

Early visual cortex (V1-V3) is believed to be critical for normal visual awareness by providing the necessary feedforward input. However, it remains unclear whether visual awareness can occur without further involvement of early visual cortex, such as re-entrant feedback. It has been challenging to determine the importance of feedback activity to these areas because of the difficulties in dissociating this activity from the initial feedforward activity. Here, we applied single-pulse transcranial magnetic stimulation (TMS) over the left posterior parietal cortex to elicit phosphenes in the absence of direct visual input to early visual cortex. Immediate neural activity after the TMS pulse was assessed using the event-related optical signal (EROS), which can measure activity under the TMS coil without artifacts. Our results show that: 1) The activity in posterior parietal cortex 50 ms after TMS was related to phosphene awareness, and 2) Activity related to awareness was observed in a small portion of V1 140 ms after TMS, but in contrast (3) Activity in V2 was a more robust correlate of awareness. Together, these results are consistent with interactive models proposing that sustained and recurrent loops of activity between cortical areas are necessary for visual awareness to emerge. In addition, we observed phosphene-related activations of the anteromedial cuneus and lateral occipital cortex, suggesting a functional network subserving awareness comprising these regions, the parietal cortex and early visual cortex.

Indexed as

AwarenessPhosphenesTranscranial Magnetic StimulationVisual CortexAdultBrain MappingFemaleHumansMaleParietal LobePhotic StimulationVisual PathwaysVisual PerceptionYoung AdultEarly visual cortexEvent-related optical signal (EROS)PhosphenesSingle pulse TMSVisual awareness

Identifiers

PMID38521150
PMCPMC11194103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.