Evidence map›Paper›PMID 38520712›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

VLDL and LDL Subfractions Enhance the Risk Stratification of Individuals Who Underwent Epstein-Barr Virus-Based Screening for Nasopharyngeal Carcinoma: A Multicenter Cohort Study.

Zhenhua Zhou, Tingxi Tang, Nan Li, Qiaocong Zheng, Ting Xiao, Yunming Tian, Jianda Sun, Longshan Zhang, Xiaoqing Wang, Yingqiao Wang and 7 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03919552 phase3recruitingnot on this map

Intensity-modulated Radiation Therapy Combined With Cisplatin-based or Carboplatin-based Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma:: A Phase 3 Trial

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2018 to 2026Enrolled482ConditionsCisplatin, Carboplatin, NPCArmsDocetaxel,Carboplatin, Docetaxel,Cisplatin, Carboplatin-based concurrent chemoradiotherapy, Cisplatin-based concurrent chemoradiotherapy
NCT05682703 unknown statusnot on this map

A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites During the Occurrence and Development of Nasopharyngeal Carcinoma in Southern China.

TypeobservationalSponsorNanfang Hospital, Southern Medical UniversityRan2022 to 2025Enrolled2,000ConditionsNasopharyngeal Carcinoma, EBV InfectionArmsProteomics technology and liquid biopsy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Zhenhua ZhouDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0001-5463-9393
Tingxi TangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Nan LiDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Qiaocong ZhengDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ting XiaoDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yunming TianDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jianda SunDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Longshan ZhangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiaoqing WangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yingqiao WangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Feng YeDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zekai ChenDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Hanbin ZhangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiuting ZhengDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhen CaiDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Laiyu LiuChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jian GuanDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-1913-1460
Nanfang Hospital · CNKey Laboratory of Guangdong Province · CNMeizhou City People's Hospital · CN

Funding

China Postdoctoral Science Foundation 2023M741560Clinical Research Program of Nanfang Hospital Southern Medical University 2018CR021Clinical Research Program of Nanfang Hospital Southern Medical University 2020CR025Clinical Research Program of Nanfang Hospital Southern Medical University 2022CR011Clinical Research Program of Nanfang Hospital Southern Medical University 2022CR013Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education LC2016PY015Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education LC2019ZD008College Students' Innovative Entrepreneurial Training Plan Program 202212121009Guangdong Basic and Applied Basic Research Foundation 2022A1515010509Medical Scientific Research Foundation of Guangdong Province B2021449National Natural Science Foundation of China 81870026National Natural Science Foundation of China 82272729Natural Science Foundation of Guangdong Province 2023A1515010285President Foundation of Nanfang Hospital, Southern Medical University 2020C044President Foundation of Nanfang Hospital, Southern Medical University 2023B046
6 · The paper itself

Abstract

Serological tests for Epstein-Barr virus (EBV) antibodies have been widely conducted for the screening of nasopharyngeal carcinoma (NPC) in endemic areas. Further risk stratification of NPC can be achieved through plasma lipoprotein and metabolic profiles. A total of 297 NPC patients and 149 EBV-positive participants are enrolled from the NCT03919552 and NCT05682703 cohorts for plasma nuclear magnetic resonance (NMR) metabolomic analysis. Small, dense very low density lipoprotein particles (VLDL-5) and large, buoyant low density lipoprotein particles (LDL-1) are found to be closely associated with nasopharyngeal carcinogenesis. Herein, an NMR-based risk score (NRS), which combines lipoprotein subfractions and metabolic biomarkers relevant to NPC, is developed and well validated within a multicenter cohort. Combining the median cutoff value of the NRS (N

Indexed as

Epstein-Barr Virus InfectionsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdultCohort StudiesFemaleHerpesvirus 4, HumanHumansLipoproteins, LDLLipoproteins, VLDLMaleMiddle AgedRisk AssessmentLipoproteins, LDLLipoproteins, VLDLlipoprotein subfractionsmetabolic biomarkersnasopharyngeal carcinomarisk stratification

Identifiers

PMID38520712
PMCPMC11165512
OpenAlexW4393110823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.