Evidence map›Paper›PMID 38520695›Full record

ReviewThe Journal of physiology2024

Surviving birth at high altitude.

Alexandra Heath-Freudenthal, Alejandra Estrada, Inge von Alvensleben, Colleen G Julian

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alexandra Heath-FreudenthalKardiozentrum, La Paz, Bolivia.ORCID 0000-0001-8732-2675
Alejandra EstradaKardiozentrum, La Paz, Bolivia.
Inge von AlvenslebenKardiozentrum, La Paz, Bolivia.
Colleen G JulianDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0001-8857-0152
Instituto Boliviano de Ciencia y Tecnología Nuclear · BOUniversity of Colorado Denver · US

Funding

Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growthR01HD088590 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Colleen Glyde Julian, LORNA G. MOORE · 2016 to 2026
$4.3M
Epigenetic and Fetal Origins of Hypoxia-Induced Pulmonary HypertensionR01HL138181 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE · 2018 to 2021
$1.6M
Novel NF-kB variant in preeclampsiaR21HD111905 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE · 2024 to 2025
$429k
Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in BoliviaR21TW010797 · FIC · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE, MOORE, LORNA G. · 2017 to 2018
$389k
FIC NIH HHS R21 TW010797NHLBI NIH HHS R01 HL138181NICHD NIH HHS R01 HD088590NICHD NIH HHS R21 HD111905
6 · The paper itself

Abstract

This Symposium Review examines challenges to surviving birth and infancy at high altitudes. Chronic exposure to the environmental hypoxia of high altitudes increases the incidence of maternal vascular disorders of pregnancy characterized by placental insufficiency, restricted fetal growth and preterm delivery, and impairs pulmonary vascular health during infancy. While each condition independently contributes to excess morbidity and mortality in early life, evidence indicates vascular disorders of pregnancy and infantile pulmonary vascular dysfunction are intertwined. By integrating our recent scientific and clinical observations in Bolivia with existing literature, we propose potential avenues to reduce the infant mortality burden at high altitudes and reduce pulmonary vascular disease in highland neonates, and emphasize the need for further research to address unresolved questions.

Indexed as

AltitudeBoliviaFemaleHumansHypoxiaInfant, NewbornPregnancyhypoxiapostnatal adaptationpreeclampsiapulmonary hypertensionsudden infant death

Identifiers

PMID38520695
PMCPMC11418585
OpenAlexW4393111331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.