Evidence map›Paper›PMID 38520508›Full record

ArticlePediatric cardiology2024

Limited Relationship Between Echocardiographic Measures and Electrocardiographic Markers of Left Ventricular Size in Healthy Children.

Mark E Alexander, Russell Gongwer, Felicia L Trachtenberg, L LuAnn Minich, John K Triedman, Jonathan R Kaltman, Richard J Czosek, Martin Tristani-Firouzi, Martin J LaPage, Sabrina S Tsao and 17 more

Abstract read
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In one paragraph

Article in Pediatric cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Mark E AlexanderBoston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. Mark.alexander@cardio.chboston.org.
Russell GongwerHealthCore, Watertown, MA, USA.
Felicia L TrachtenbergHealthCore, Watertown, MA, USA.
L LuAnn MinichUniversity of Utah, Salt Lake City, UT, USA.
John K TriedmanBoston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Jonathan R KaltmanNIH, Bethesda, USA.
Richard J CzosekCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Martin Tristani-FirouziUniversity of Utah, Salt Lake City, UT, USA.
Martin J LaPageCS Mott Children's Hospital, Ann Arbor, MI, USA.
Sabrina S TsaoAnn and Robert H. Lurie Children's Hospital, Chicago, IL, USA.
Andrew E RadbillVanderbilt University, Nashville, TN, USA.
Michael P DiLorenzoColumbia University Irving Medical Center, New York, NY, USA.
Joshua R KovachMedical College of Wisconsin, Milwaukee, WI, USA.
Elizabeth A StephensonThe Hospital for Sick Children, Toronto, ON, USA.
Christopher JansonCHOP, Philadelphia, PA, USA.
Chad MaoChildren's Healthcare of Atlanta, Atlanta, GA, USA.
Jack C SalernoSeattle Children's Hospital, Seattle, WA, USA.
Bradley C ClarkChildren's Hospital at Montefiore, New York, NY, USA.
Joseph MahgereftehChildren's Hospital at Montefiore, New York, NY, USA.
Thomas PilcherUniversity of Utah, Salt Lake City, UT, USA.
Tiffanie R JohnsonIndiana University School of Medicine, Indianapolis, IN, USA.
Jeff J KimTexas Children's Hospital, Houston, TX, USA.
Santiago O ValdesTexas Children's Hospital, Houston, TX, USA.
Nicole CainMedical University of South Carolina, Charleston, SC, USA.
Lanier JacksonMedical University of South Carolina, Charleston, SC, USA.
Elizabeth V SaarelSt. Luke's Health System, Boise, ID, USA.
Pediatric Heart Network Investigators

Funding

Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9M
Ventricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3M
MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C ProgramU24HL135691 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2017 to 2024
$37.9M
Pediatric Heart Network Clinical Research Centers - Boston Children's HospitalUG1HL135685 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., TRIEDMAN, JOHN K · 2017 to 2023
$2.7M
Pediatric Heart Network Children's Hospital of PhiladelphiaUG1HL135683 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GAYNOR, JAMES WILLIAM, GOLDBERG, DAVID J · 2017 to 2023
$2.6M
Baylor/Texas Children's Hospital Pediatric Heart NetworkUG1HL135666 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HEINLE, JEFFREY STEPHEN, PENNY, DANIEL J · 2017 to 2023
$2.4M
Pediatric Heart Network Prairieland ConsortiumUG1HL135678 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, PAYNE, RONALD MARK · 2017 to 2023
$2.4M
Pediatric Heart Network Regents of the University of MichiganUG1HL135665 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDBERG, CAREN S, OHYE, RICHARD G · 2017 to 2023
$2.4M
Pediatric Heart Network - Utah CenterUG1HL135646 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2017 to 2023
$2.3M
Pediatric Heart Network Clinical Research Center - Medical University of South CarolinaUG1HL135689 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ATZ, ANDREW M, GRAHAM, ERIC M. · 2017 to 2023
$2.3M
Pediatric Heart Network Emory UniversityUG1HL135682 · NHLBI · EMORY UNIVERSITY · PI BOOK, WENDY M., KOCHILAS, LAZAROS K. · 2017 to 2023
$2.2M
Pediatric Heart Network - The Hospital for Sick Children, TorontoUG1HL135680 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W, MITAL, SEEMA · 2017 to 2023
$1.7M
NHLBI NIH HHS HL068270NHLBI NIH HHS HL135646NHLBI NIH HHS HL135665NHLBI NIH HHS HL135666NHLBI NIH HHS HL135678NHLBI NIH HHS HL135680NHLBI NIH HHS HL135682NHLBI NIH HHS HL135683NHLBI NIH HHS HL135685NHLBI NIH HHS HL135689NHLBI NIH HHS HL135691
6 · The paper itself

Abstract

Pediatric ECG standards have been defined without echocardiographic confirmation of normal anatomy. The Pediatric Heart Network Normal Echocardiogram Z-score Project provides a racially diverse group of healthy children with normal echocardiograms. We hypothesized that ECG and echocardiographic measures of left ventricular (LV) dimensions are sufficiently correlated in healthy children to imply a clinically meaningful relationship. This was a secondary analysis of a previously described cohort including 2170 digital ECGs. The relationship between 6 ECG measures associated with LV size were analyzed with LV Mass (LVMass-z) and left ventricular end-diastolic volume (LVEDV-z) along with 11 additional parameters. Pearson or Spearman correlations were calculated for the 78 ECG-echocardiographic pairs with regression analyses assessing the variance in ECG measures explained by variation in LV dimensions and demographic variables. ECG/echocardiographic measurement correlations were significant and concordant in 41/78 (53%), though many were significant and discordant (13/78). Of the 6 ECG parameters, 5 correlated in the clinically predicted direction for LV Mass-z and LVEDV-z. Even when statistically significant, correlations were weak (0.05-0.24). R

Indexed as

EchocardiographyElectrocardiographyHeart VentriclesAdolescentChildChild, PreschoolFemaleHumansInfantMaleOrgan SizeReference ValuesStroke VolumeEchocardiogramElectrocardiogramLeft ventricular hypertrophy

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.