Evidence map›Paper›PMID 38520049›Full record

ArticleMolecular oncology2024

Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells.

Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H Krämer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anita G KansyInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Ramy AshryInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Al-Hassan M MustafaInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Abdallah M AlfayomyDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany.
Markus P Radsak3rd Department Medicine, University Medical Center Mainz, Germany.
Yanira ZeynDepartment of Dermatology, University Medical Center Mainz, Germany.
Matthias BrosDepartment of Dermatology, University Medical Center Mainz, Germany.
Wolfgang SipplDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-5985-9261
Oliver H KrämerInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0003-3973-045X
Johannes Gutenberg University Mainz · DEAl-Azhar University · EGMansoura University · EGMartin Luther University Halle-Wittenberg · DE

Funding

Brigitte und Dr. Konstanze Wegener-StiftungDeutsche Forschungsgemeinschaft KR2291Deutsche Forschungsgemeinschaft SFB1292TP21NDeutsche Forschungsgemeinschaft SFB1361Deutsche Forschungsgemeinschaft SI868/22-1German Academic Exchange serviceWalter Schulz-Stiftung
6 · The paper itself

Abstract

Mammalian cells replicate ~ 3 × 10

Indexed as

Ataxia Telangiectasia Mutated ProteinsCell ProliferationDNA ReplicationLeukemiaAdaptor Proteins, Signal TransducingCell Line, TumorDNA DamageHumansHydroxyureaProteolysisUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingAtaxia Telangiectasia Mutated ProteinsATR protein, humanCRBN protein, humanHydroxyureaUbiquitin-Protein LigasesATRcereblonDNA replication stressleukemiaPROTAC

Identifiers

PMID38520049
PMCPMC11306515
OpenAlexW4393116348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.