Evidence map›Paper›PMID 38520024›Full record

ArticleBMC medicine2024

Sarcopenic obesity is part of obesity paradox in dementia development: evidence from a population-based cohort study.

Junhan Zhang, Xiaona Na, Zhihui Li, John S Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Junhan ZhangVanke School of Public Health, Tsinghua University, Beijing, China.
Xiaona NaVanke School of Public Health, Tsinghua University, Beijing, China.
Zhihui LiVanke School of Public Health, Tsinghua University, Beijing, China.
John S JiVanke School of Public Health, Tsinghua University, Beijing, China.
Guowei LiCenter for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Haibing YangVanke School of Public Health, Tsinghua University, Beijing, China.
Yucheng YangVanke School of Public Health, Tsinghua University, Beijing, China.
Yuefeng TanVanke School of Public Health, Tsinghua University, Beijing, China.
Jian ZhangSchool of Public Health, Peking University, Beijing, China.
Menglu XiVanke School of Public Health, Tsinghua University, Beijing, China.
Donghan SuVanke School of Public Health, Tsinghua University, Beijing, China.
Huatang ZengVanke School of Public Health, Tsinghua University, Beijing, China.
Liqun WuShenzhen Health Development Research and Data Management Center, Shenzhen, Guangdong, China.
Ai ZhaoVanke School of Public Health, Tsinghua University, Beijing, China. aizhao18@mail.tsinghua.edu.cn.
Vanke (China) · CNTsinghua University · CNPeking University · CN

Funding

Sanming Project of Medicine in Shenzen Municipality SZSM202111001
6 · The paper itself

Abstract

backgroundSarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset.

methodsWe included 208,867 participants from UK biobank, who aged 60 to 69 years at baseline. Dementia diagnoses were identified using hospital records and death register data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models to evaluate the associations of obesity, sarcopenia, and sarcopenic obesity with dementia risk, stratified by sex. Stratified analyses were performed across dementia-related polygenic risk score (PRS). Restricted mean survival time models were established to estimate the difference and 95%CIs of dementia onset across different status. Additionally, linear regression models were employed to estimate associations of different status with brain imaging parameters. The mediation effects of chronic diseases were also examined.

resultsObese women with high PRS had a decreased risk (HR = 0.855 [0.761-0.961]), but obese men with low PRS had an increased risk (HR = 1.223 [1.045-1.431]). Additionally, sarcopenia was associated with elevated dementia risk (HR

conclusionsSarcopenic obesity and sarcopenia were respectively associated with increased dementia risk and advanced dementia onset to vary degree. The role of obesity in dementia may differ by sex and genetic background.

Indexed as

DementiaSarcopeniaChronic DiseaseCohort StudiesFemaleGenetic Risk ScoreHumansMaleObesityObesity ParadoxBrain structureDementiaObesityOnsetSarcopeniaSarcopenic obesity

Identifiers

PMID38520024
PMCPMC10960494
OpenAlexW4393067818

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.