Evidence map›Paper›PMID 38519979›Full record

ArticleGenome biology2024

txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility.

Hao Zhang, Ryan M Mulqueen, Natalie Iannuzo, Dominique O Farrera, Francesca Polverino, James J Galligan, Julie G Ledford, Andrew C Adey, Darren A Cusanovich

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hao Zhang *Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Ryan M Mulqueen *Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Natalie IannuzoDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Dominique O FarreraDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA.
Francesca PolverinoAsthma & Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
James J GalliganDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA.
Julie G LedfordDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Andrew C AdeyDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu.
Darren A CusanovichDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. darrenc@arizona.edu.ORCID 0000-0001-6889-0095
University of Arizona · USOregon Health & Science University · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Training in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
Defining the epigentic landscape at single cell resolutionR35GM124704 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADEY, ANDREW · 2017 to 2021
$2.3M
Establishing Glyoxalase 2 as a Viable Target for the Treatment of Disease [Equipment Supplement]R35GM137910 · NIGMS · UNIVERSITY OF ARIZONA · PI GALLIGAN, JAMES J · 2020 to 2024
$2.1M
High-content single-cell epigenetic technologies scalable to the human brainRF1MH128842 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADEY, ANDREW · 2021 to 2021
$1.9M
Beyond Pseudotime: Enhanced Single-cell Genomics Tools for Understanding the Temporal Dynamics of Development and DiseaseR35GM137896 · NIGMS · UNIVERSITY OF ARIZONA · PI CUSANOVICH, DARREN A · 2020 to 2024
$1.8M
Glyoxalase 1 and its Role in Metabolic SyndromeR01DK133196 · NIDDK · UNIVERSITY OF ARIZONA · PI James J Galligan · 2023 to 2026
$1.8M
NHLBI NIH HHS R01 HL142769NHLBI NIH HHS R01HL142769NIEHS NIH HHS P30 ES006694NIEHS NIH HHS T32 ES007091NIEHS NIH HHS T32ES007091NIGMS NIH HHS R35 GM124704NIGMS NIH HHS R35GM124704NIGMS NIH HHS R35 GM137896NIGMS NIH HHS R35GM137896NIGMS NIH HHS R35 GM137910NIGMS NIH HHS R35GM137910NIMH NIH HHS RF1 MH128842NIMH NIH HHS RF1MH128842
6 · The paper itself

Abstract

We develop a large-scale single-cell ATAC-seq method by combining Tn5-based pre-indexing with 10× Genomics barcoding, enabling the indexing of up to 200,000 nuclei across multiple samples in a single reaction. We profile 449,953 nuclei across diverse tissues, including the human cortex, mouse brain, human lung, mouse lung, mouse liver, and lung tissue from a club cell secretory protein knockout (CC16

Indexed as

ChromatinChromatin Immunoprecipitation SequencingAnimalsCell NucleusHumansMiceRegulatory Sequences, Nucleic AcidChromatinATAC-seqCC16Chromatin accessibilityCombinatorial indexingMolecular hashingSingle-cell

Identifiers

PMID38519979
PMCPMC10958877
OpenAlexW4393086267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.