SynthesisBMC infectious diseases2024
Clinical characteristics, diagnosis, treatment, and outcome of patients with liver abscess due to Aspergillus spp: a systematic review of published cases.
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Who cites it
17 citing papers in PubMed.
- Pulmonary Artery Mass Caused byInfectious disease reports · 2026Article
- Evolving management of pyogenic liver abscess: A narrative review of laparoscopic and open drainage approaches with contextual insights from Pakistan.Pakistan journal of medical sciences · 2026Review
- Pyogenic Hepatic Abscess as a Complication of Appendicitis: A Case Report.Clinical case reports · 2026Article
- Disseminated Invasive Aspergillosis in a Young Patient With Chronic Alcohol Use and Seemingly Preserved Immunocompetence: A Case Report.Clinical case reports · 2026Article
- A rare case report of pyogenic hepatic abscess secondary to sigmoid diverticulitis.SAGE open medical case reports · 2026Article
- The Abscess That Was Cancer: Pyogenic Liver Abscess as the Initial Manifestation of Hepatocellular Carcinoma in a Noncirrhotic Patient.Case reports in hepatology · 2026Article
- A rare case of hepatic abscess due toSAGE open medical case reports · 2026Article
- Aeromonas caviae: A rare case of hepatic abscess.GMS hygiene and infection control · 2026Article
- Central nervous system Aspergillus fumigatus infection with subarachnoid haemorrhage secondary to hemophagocytic lymphohistiocytosis: a rare case report.BMC neurology · 2025Article
- Development and validation of a nomogram for predicting antibiotic treatment duration in patients with liver abscess complicated by diabetes.Scientific reports · 2025Article
- Fungal Pericarditis-A Systematic Review of 101 Cases.Microorganisms · 2025Review
- Massive Sequencing of V3-V4 Hypervariable Region in Pyogenic Liver Abscesses Reveals the Presence of Unusual Bacteria Not Detected by Classical Culture Methods.Microorganisms · 2025Article
- Amoebic liver abscess co-infected with bacterial liver abscess: A rare case in an immunocompromised patient.IDCases · 2025Article
- Etiology, Risk Factors, and Antimicrobial Resistance in Recurrent Pyogenic Liver Abscesses: A Six-Year Analysis.Infection and drug resistance · 2025Article
- Successful Treatment of Pyogenic Liver Abscess Caused byInfection and drug resistance · 2025Article
- Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study.International medical case reports journal · 2025Article
- Case report: Trauma-inducedFrontiers in medicine · 2024Article
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12 authors.
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Abstract
backgroundAspergillus spp liver abscess is a relatively rare entity and thus far no systematic review has been performed examining patients' demographics, clinical manifestations, diagnosis, management, and outcome.
methodsWe performed a systematic review of the literature using MEDLINE and LILACS databases. We searched for articles published in the period from January 1990 to December 24, 2022, to identify patients who developed liver abscesses due to Aspergillus spp.
resultsOur search yielded 21 patients all of whom had invasive aspergillosis confirmed on liver biopsy. Of these patients 81% were adults, and 60% were males. The majority (86%) of patients were immunocompromised and 95% had symptomatic disease at the time of diagnosis. The most common symptoms were fever (79%), abdominal pain (47%), and constitutional symptoms (weight loss, chills, night sweats, fatigue) (38%). Liver enzymes were elevated in 50%, serum galactomannan was positive in 57%, and fungal blood cultures were positive in only 11%. Co-infection with other pathogens preceded development of apsergillosis in one-third of patients, and the majority of the abscesses (43%) were cryptogenic. In the remaining patients with known source, 28% of patients developed liver abscess through dissemination from the lungs, 19% through the portal vein system, and in 10% liver abscess developed through contiguous spread. The most common imaging modality was abdominal computerized tomography done in 86% of patients. Solitary abscess was present in 52% of patients while 48% had multiple abscesses. Inadequate initial empiric therapy was prescribed in 60% of patients and in 44% of patients definite treatment included combination therapy with two or more antifungal agents. Percutaneous drainage of the abscesses was done in 40% of patients, while 20% required liver resection for the treatment of the abscess. Overall mortality was very high at 38%.
conclusionFurther studies are urgently needed for a better understanding of pathophysiology of liver aspergillosis and for developement of newer blood markers in order to expedite diagnosis and decrease mortality.
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