Evidence map›Paper›PMID 38519706›Full record

ArticleBritish journal of cancer2024

Persistence of peripheral CD8 + CD28- T cells indicates a favourable outcome and tumour immunity in first-line HER2-positive metastatic breast cancer.

Xiaoran Liu, Xiangming Cheng, Feng Xie, Kun Li, Yongcan Shi, Bin Shao, Xu Liang, Fengling Wan, Shidong Jia, Yue Zhang and 2 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Xiaoran Liu *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China.ORCID 0000-0003-0912-3210
Xiangming Cheng *Jin Xiang People's Hospital, Department of Hematologic Oncology, Jining, Shandong, China.
Feng Xie *Huidu (Shanghai) Medical Sciences, Ltd., Shanghai, China.
Kun LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China.
Yongcan ShiJin Xiang People's Hospital, Department of Hematologic Oncology, Jining, Shandong, China.
Bin ShaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China.
Xu LiangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China.
Fengling WanKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China.
Shidong JiaHuidu (Shanghai) Medical Sciences, Ltd., Shanghai, China.
Yue ZhangHuidu (Shanghai) Medical Sciences, Ltd., Shanghai, China.
Yiqiang LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China. victor.liu76@163.com.ORCID 0000-0002-7239-2360
Huiping LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Fu-Cheng road No. 52, Hai-Dian District, Beijing, China. huipingli2012@hotmail.com.ORCID 0000-0002-3331-647X
Peking University · CN

Funding

Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 7212011
6 · The paper itself

Abstract

backgroundThe contradictory role of CD8 + CD28- T cells in tumour immunity has been reported, while their biological and clinical significance in HER2-positive metastatic breast cancer (MBC) is still unknown.

methodsHER2-positive MBC patients with no prior therapy in the metastatic setting were retrospectively recruited at two medical centres. Peripheral CD8 + CD28- T cells (pT

resultsA total of 252 patients were enrolled, and the median follow-up time was 29.6 months. pT

conclusionsHigh pT

Indexed as

Breast NeoplasmsCD28 AntigensCD8-Positive T-LymphocytesErb-b2 Receptor Tyrosine KinasesAdultFemaleHumansNeoplasm MetastasisProgression-Free SurvivalRetrospective StudiesCD28 AntigensERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID38519706
PMCPMC11091143
OpenAlexW4393078474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.