ArticleNature communications2024
Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
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- Indocyanine Green-Inspired Polymeric Chromophores With Intrinsic Photostability for Near-Infrared Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Taming boroloborinines: toward photostable polycyclic antiaromatic hydrocarbons.Chemical science · 2026Article
- Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine.Chemical science · 2026Review
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- Symmetrical D-π-A-π-D indanone dyes: a new design for nonlinear optics and cyanide detection.Beilstein journal of organic chemistry · 2026Article
- Advances in NIR-II Fluorescence Laparoscopy for Precision Diagnosis and Theranostics of Urological Oncology.International journal of nanomedicine · 2026Review
- Spatial fluorescence barcode by transiently luminescent DNA beads.Nature communications · 2025Article
- Reduction of photobleaching effects in photoacoustic imaging using noise agnostic, platform-flexible deep-learning methods.Journal of biomedical optics · 2025Article
- Fluorescent solvatochromism and nonfluorescence processes of charge-transfer-type molecules with a 4-nitrophenyl moiety.RSC advances · 2025Article
- Molecular design and excited state dynamics regulation in phototheranostics.Biophysics reports · 2025Article
- Structural and Electronic Properties of D-π-A Coumarin Dyes: A DFT/TD-DFT Assisted Design of Low-Molecular-Weight, Long-Wavelength-Emissive Fluorescent Dyes.Journal of fluorescence · 2025Article
- Design of Orthogonal Far-Red, Orange and Green Fluorophore-binding Proteins for Multiplex Imaging.bioRxiv : the preprint server for biology · 2025Article
- Advancing Single-Molecule Biophysics: Next-Generation Organic Fluorophores with Tailored Labeling Strategies.Chemical & biomedical imaging · 2025Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Long-wavelength, near-infrared small-molecule dyes are attractive in biophotonics. Conventionally, they rely on expanded aromatic structures for redshift, which comes at the cost of application performance such as photostability, cell permeability, and functionality. Here, we report a ground-state antiaromatic strategy and showcase the concise synthesis of 14 cationic aminofluorene dyes with mini structures (molecular weights: 299-504 Da) and distinct spectra covering 700-1600 nm. Aminofluorene dyes are cell-permeable and achieve rapid renal clearance via a simple 44 Da carboxylation. This accelerates optical diagnostics of renal injury by 50 min compared to existing macromolecular approaches. We develop a compact molecular sensing platform for in vivo intracellular sensing, and demonstrate the versatile applications of these dyes in multispectral fluorescence and optoacoustic imaging. We find that aromaticity reversal upon electronic excitation, as indicated by magnetic descriptors, not only reduces the energy bandgap but also induces strong vibronic coupling, resulting in ultrafast excited-state dynamics and unparalleled photostability. These results support the argument for ground-state antiaromaticity as a useful design rule of dye development, enabling performances essential for modern biophotonics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.