Evidence map›Paper›PMID 38519475›Full record

ArticleNature communications2024

Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling.

Gabriel M F Batista, Ruth Ebenbauer, Craig Day, Jonas Bergare, Karoline T Neumann, Kathrin H Hopmann, Charles S Elmore, Alonso Rosas-Hernández, Troels Skrydstrup

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Photolysis of COJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. COTopics in current chemistry (Cham) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriel M F BatistaCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark.ORCID http://orcid.org/0000-0003-0541-9065
Ruth EbenbauerCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark.ORCID http://orcid.org/0000-0001-7101-6972
Craig DayCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-6931-0280
Jonas BergareEarly Chemical Development, Pharmaceutical Sciences R&D AstraZeneca, Gothenburg, Sweden.
Karoline T NeumannCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-4795-822X
Kathrin H HopmannDepartment of Chemistry, UiT-The Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0003-2798-716X
Charles S ElmoreEarly Chemical Development, Pharmaceutical Sciences R&D AstraZeneca, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-7434-8307
Alonso Rosas-HernándezCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark. arosas@chem.au.dk.ORCID http://orcid.org/0000-0002-0812-5591
Troels SkrydstrupCarbon Dioxide Activation Center (CADIAC), Novo Nordisk Foundation CO2 Research Center, Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark. ts@chem.au.dk.ORCID http://orcid.org/0000-0001-8090-5050

Funding

Danmarks Grundforskningsfond (Danish National Research Foundation) DNRF118Norges Forskningsråd (Research Council of Norway) no. 300769Novo Nordisk Fonden (Novo Nordisk Foundation) NNF23OC0081745
6 · The paper itself

Abstract

Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs ubiquitous in pharmaceutically active molecules and are ideal targets for the installation of a radioactive tag employing isotopically labelled CO

Indexed as

CarbonPalladiumCarbon DioxideCarbon IsotopesCarbon RadioisotopesCatalysisIsotope LabelingCarbonCarbon-14Carbon DioxideCarbon IsotopesCarbon RadioisotopesPalladium

Identifiers

PMID38519475
PMCPMC10959938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.