Evidence map›Paper›PMID 38519444›Full record

ArticlePerfusion2025

The role of fetal hemoglobin in the artificial placenta: A premature ovine model.

Brianna L Spencer, Brian P Fallon, Jennifer S McLeod, Marie Cornell, Erin E Perrone, David M Manthei, Alvaro Rojas-Peña, Ronald B Hirschl, Robert H Bartlett, George B Mychaliska

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Brianna L SpencerDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-5054-4458
Brian P FallonDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Jennifer S McLeodDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Marie CornellDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Erin E PerroneDepartment of Surgery, Section of Pediatric Surgery, University of Michigan Michigan Medicine, Ann Arbor, MI, USA.
David M MantheiDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Alvaro Rojas-PeñaDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-6197-8892
Ronald B HirschlDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Robert H BartlettDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
George B MychaliskaDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-1572-5752
University of Michigan · USMichigan Medicine · US

Funding

Development of an Artificial Placenta for Support of Premature InfantsR01HD073475 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYCHALISKA, GEORGE BORIS · 2014 to 2018
$2.7M
NICHD NIH HHS R01 HD073475
6 · The paper itself

Abstract

introductionA radical paradigm shift in the treatment of premature infants failing conventional treatment is to recreate fetal physiology using an extracorporeal Artificial Placenta (AP). The aim of this study is to evaluate the effects of changing fetal hemoglobin percent (HbF%) on physiology and circuit function during AP support in an ovine model.

methodsExtremely premature lambs (

resultsThe mean survival time on circuit was 119.6 ± 39.5 h. Hemodynamic parameters and lactate were stable throughout. As more adult blood transfusions were given to maintain hemoglobin at 10 mg/dL, the HbF% declined, reaching 40% by post operative day 7. The HbF% was inversely proportional to flow rates as higher flows were required to maintain adequate oxygen saturation and perfusion.

conclusionsTransfusion of adult blood led to decreased fetal hemoglobin concentration during AP support. The HbF% was inversely proportional to flow rates. Future directions include strategies to decrease the priming volume and establishing a fetal blood bank to have blood rich in HbF.

Indexed as

Fetal HemoglobinPlacentaAnimalsFemalePregnancySheepFetal Hemoglobinartificial placentaclinical translationextremely low gestational age newbornsfetal blood bankfetal hemoglobin

Identifiers

PMID38519444
PMCPMC11416565
OpenAlexW4393118041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.