Evidence map›Paper›PMID 38519422›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Biosynthesis of Strained Amino Acids by a PLP-Dependent Enzyme through Cryptic Halogenation.

Max B Sosa, Jacob T Leeman, Lorenzo J Washington, Henrik V Scheller, Michelle C Y Chang

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Max B SosaDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460, USA.
Jacob T LeemanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460, USA.
Lorenzo J WashingtonDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA 94720-3102, USA.
Henrik V SchellerDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA 94720-3102, USA.
Michelle C Y ChangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460, USA.ORCID 0000-0003-3747-7630

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Proposal for Central California 900 MHZ NMR SpectrometerP41GM068933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEMMER, DAVID E · 2003 to 2007
$5.9M
Discovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
Biological and Environmental Research DE-AC02-05CH11231National Science Foundation Graduate Research Fellowship Program DGE 2146752NIGMS NIH HHS R01 GM134271NIGMS NIH HHS T32 GM066698NIH HHS GM68933NIH HHS R01 GM134271NIH HHS S10OD024998NIH HHS T32 GMO66698Novo Nordisk Foundation Center for Basic Metabolic Research NNF19SA0059362
6 · The paper itself

Abstract

Amino acids (AAs) are modular building blocks which nature uses to synthesize both macromolecules, such as proteins, and small molecule natural products, such as alkaloids and non-ribosomal peptides. While the 20 main proteinogenic AAs display relatively limited side chain diversity, a wide range of non-canonical amino acids (ncAAs) exist that are not used by the ribosome for protein synthesis, but contain a broad array of structural features and functional groups. In this communication, we report the discovery of the biosynthetic pathway for a new ncAA, pazamine, which contains a cyclopropane ring formed in two steps. In the first step, a chlorine is added onto the C

Indexed as

Amino AcidsHalogenationArabidopsisCyclopropanesPseudomonasPyridoxal PhosphateAmino AcidsCyclopropanesPyridoxal Phosphatebiosynthesiscyclobutanescyclopropanesnon-canonical amino acidspyridoxal phosphate (PLP)

Identifiers

PMID38519422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.