ArticleLupus science & medicine2024
Association of phenotypic frailty and hand grip strength with telomere length in SLE.
Article in Lupus science & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Leukocyte Telomere Length and Long-Term Clinical Outcomes in Women with Systemic Lupus Erythematosus: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Handgrip strength testing in rheumatic diseases.Rheumatology international · 2026Review
- The High Prevalence of High Normal Blood Pressure and the Differential Association of Grip Strength Metrics with Hypertension in a National Sample of Chinese College Students.Journal of clinical medicine · 2026Article
- Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases.ACR open rheumatology · 2025Article
- Association of frailty and its trajectory with the risk of cancer: evidence from the China health and retirement longitudinal study (CHARLS).BMC public health · 2025Article
- Frailty in older adults with systemic lupus erythematosus and emergency department utilization: an administrative claims data analysis of Medicare beneficiaries.Clinical rheumatology · 2025Article
- Association Between Frailty Status and Readmissions in Hospitalized Patients With Systemic Lupus Erythematosus.ACR open rheumatology · 2024Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveFrailty and objective hand grip strength (one of the components of the frailty phenotype) are both risk factors for worse health outcomes in SLE. Whether telomere length, an established cellular senescence marker, is a biologic correlate of the frailty phenotype and hand grip strength in patients with SLE is not clear. First, we aimed to evaluate differences in telomere length between frail and non-frail women with SLE and then assessed whether frailty or hand grip strength is differentially associated with telomere length after adjusting for relevant confounders.
methodsWomen ≥18 years of age with validated SLE enrolled at a single medical centre. Fried frailty status (which includes hand grip strength), clinical characteristics and telomere length were assessed cross-sectionally. Differences between frail and non-frail participants were evaluated using Fisher's exact or Wilcoxon rank-sum tests. The associations between frailty and hand grip strength and telomere length were determined using linear regression.
resultsOf the 150 enrolled participants, 131 had sufficient data for determination of frailty classification; 26% were frail with a median age of 45 years. There was a non-significant trend towards shorter telomere length in frail versus non-frail participants (p=0.07). Hand grip strength was significantly associated with telomere length (beta coefficient 0.02, 95% CI 0.004, 0.04), including after adjustment for age, SLE disease activity and organ damage, and comorbidity (beta coefficient 0.02, 95% CI 0.002, 0.04).
conclusionsDecreased hand grip strength, but not frailty, was independently associated with shortened telomere length in a cohort of non-elderly women with SLE. Frailty in this middle-aged cohort may be multifactorial rather than strictly a manifestation of accelerated ageing.
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