Evidence map›Paper›PMID 38518980›Full record

ReviewThe international journal of biochemistry & cell biology2024

Regulatory T cells: Supporting lung homeostasis and promoting resolution and repair after lung injury.

Morgan J McCullough, Pria G Bose, Jason R Mock

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The international journal of biochemistry & cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Morgan J McCulloughDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Marsico Lung Institute, School of Medicine, University of North Carolina Chapel Hill, NC, USA.
Pria G BoseMarsico Lung Institute, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina Chapel Hill, NC, USA.
Jason R MockDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Marsico Lung Institute, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine School of Medicine, University of North Carolina Chapel Hill, NC, USA. Electronic address: jason_mock@med.unc.edu.

Funding

Defining the Role of Regulatory T Cells in Resolution of Acute Lung InjuryR01HL152077 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOCK, JASON ROBERT · 2021 to 2025
$2.9M
NHLBI NIH HHS R01 HL152077
6 · The paper itself

Abstract

Regulatory T cells, characterized by their expression of the transcription factor Forkhead box P3, are indispensable in maintaining immune homeostasis. The respiratory system is constantly exposed to many environmental challenges, making it susceptible to various insults and infections. Regulatory T cells play essential roles in maintaining homeostasis in the lung and promoting repair after injury. Regulatory T cell function dysregulation can lead to inflammation, tissue damage, or aberrant repair. Research on regulatory T cell mechanisms in the lung has unveiled their influence on lung inflammation and repair mechanisms. In this review, our goal is to highlight the advances in regulatory T cell biology with respect to lung injury and resolution. We further provide a perspective that a deeper understanding of regulatory T cell interactions in the lung microenvironment in health and disease states offers opportunities for therapeutic interventions as treatments to promote lung health.

Indexed as

Lung InjuryForkhead Transcription FactorsHomeostasisHumansInflammationLungT-Lymphocytes, RegulatoryForkhead Transcription FactorsLung immunologyLung injuryRegulatory T cellResolution

Identifiers

PMID38518980
PMCPMC11031275

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.