Evidence map›Paper›PMID 38518897›Full record

ReviewJournal of thrombosis and haemostasis : JTH2024

Recent advances in vascular thiol isomerases and redox systems in platelet function and thrombosis.

David W Essex, Lu Wang

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of thrombosis and haemostasis : JTH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

  1. Molecular mechanisms of protein disulfide isomerase antagonism by punicalagin.Biochemical and biophysical research communications · 2026
    Article
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  6. Review
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  9. The crucial role of thromboxane AFrontiers in pharmacology · 2026
    Review
  10. Article
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  12. Review
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  16. Review
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  18. Platelets welcome a new protein disulfide isomerase family member.Journal of thrombosis and haemostasis : JTH · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David W EssexDepartment of Cardiovascular Sciences, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. Electronic address: essex@temple.edu.
Lu WangAllen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, New York, USA.
Rockefeller University · USTemple University · US

Funding

Functional Role of Protein Disulfide Isomerase Isoforms in PlateletsR01HL118526 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ESSEX, DAVID W · 2013 to 2021
$4.4M
The Transmembrane Protein Disulfide Isomerase TMX1 Negatively Regulates ThrombosisR01HL162845 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI DAVID W ESSEX · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL118526NHLBI NIH HHS R01 HL162845
6 · The paper itself

Abstract

There have been substantial advances in vascular protein disulfide isomerases (PDIs) in platelet function and thrombosis in recent years. There are 4 known prothrombotic thiol isomerases; PDI, endoplasmic reticulum protein (ERp)57, ERp72, and ERp46, and 1 antithrombotic PDI; transmembrane protein 1. A sixth PDI, ERp5, may exhibit either prothrombotic or antithrombotic properties in platelets. Studies on ERp46 in platelet function and thrombosis provide insight into the mechanisms by which these enzymes function. ERp46-catalyzed disulfide cleavage in the α

Indexed as

Blood PlateletsOxidation-ReductionProtein Disulfide-IsomerasesThrombosisAnimalsHumansMembrane GlycoproteinsMembrane ProteinsOxidative StressPlatelet ActivationPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexSulfhydryl CompoundsMembrane GlycoproteinsMembrane ProteinsPlatelet Glycoprotein GPIIb-IIIa ComplexProtein Disulfide-IsomerasesSulfhydryl Compoundsdisulfideintegrinplateletprotein disulfide isomerasesulfhydrylthrombosis

Identifiers

PMID38518897
PMCPMC11214884
OpenAlexW4392975544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.